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Protein Overview: ROG1

General Information:
Name(s) found: ROG1 / YGL144C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein with putative serine active lipase domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 685 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: lipid metabolic process [IMPLink to PubMed article]
    Molecular Function: lipase activity [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV RNMNPLSYRA  60
   61 AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ QDFVAELSVH NIRQKYVWIA 120
  121 DVMSQILFTT NTNVTYEVTI GTSKESVENP HDLPSHLGSY SPKLTVNRLT TLDLWNLPVQ 180
  181 ITTPQKKKHL VVLTHGLHSN VSTDLVYIME QIYKAQKNYP HEQIVVKGYR GNVCQTEKGV 240
  241 KYLGTRLAEY IIQDLYDESI RKISFVGHSL GGLIQAFAIA YIYEVYPWFF KKVNPINFIT 300
  301 LASPLLGIVT DNPAYIKVLL SFGVIGKTGQ DLGLENDVEV GKPLLYLLSG LPLIEILRRF 360
  361 KRRTVYANAI NDGIVPLYTA SLLFLDYNDI LEQLQKLKEN SKKSPLINDA STPVNQDFFN 420
  421 KTFISPLTKM LSILAPQKFP TENGSEIPKV SFFESASSIL LPPLPERAYI MDPDSRDPVI 480
  481 IHDKIYNEDD IPQSEFDIED GFFGKKNILL QAFFAGKKER AKYRNLEETI ARRWHEGMAW 540
  541 RKVVVALKPD AHNNIIVRRK FANAYGWPVI DHLIDVHFNG DDDDDNDEND DINSTQVVEP 600
  601 IQSVTEGKKK YRKAENIPQE YGWLNKVETN GVFDEGPTGM ISTVGEIVEA LAKRGFSAVI 660
  661 DRRNASEDPN DEVLRFEEMN SDLVQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] deduced N/A No confident structure predictions are available.
    2 View Details [177..394] PSI-BLAST 32.045757 Lipase
    3 View Details [395..685] deduced N/A No confident structure predictions are available.
    4 View Details [499..584] MSA 1.025979 View MSA. No confident structure predictions are available.
    5 View Details [585..685] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • hydrolase activity
    		•  1.1444670166202 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.985235528680562 bayes_pls_golite062009
  • lipase activity
    		•  0.849473630399459 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.424330502936163 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle