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View Structure Prediction Details

Protein: ROG1
Organism: Saccharomyces cerevisiae
Length: 685 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ROG1.

Description E-value Query
Range
Subject
Range
ROG1 - Protein with putative serine active lipase domain
ROG1_YEAST - Putative lipase ROG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ROG1 PE=1 SV=1
0.0 [1..685] [1..685]
YE7A_SCHPO - Putative lipase spac4a8.10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4A8.10 PE=2...
SPAC4A8.10 - lipase
0.0 [46..578] [108..689]
gi|222422961, gi... - gi|30696012|ref|NP_851167.1| unknown protein [Arabidopsis thaliana], gi|222422961|dbj|BAH19465.1| AT...
1.0E-53 [170..442] [18..319]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-47 [187..442] [79..364]
gi|608526 - gi|608526|gb|AAA95966.1| lipase-esterase
7.0E-43 [181..410] [12..253]

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Predicted Domain #1
Region A:
Residues: [1-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV RNMNPLSYRA  60
   61 AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ QDFVAELSVH NIRQKYVWIA 120
  121 DVMSQILFTT NTNVTYEVTI GTSKESVENP HDLPSHLGSY SPKLTVNRLT TLDLWN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [177-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPVQITTPQK KKHLVVLTHG LHSNVSTDLV YIMEQIYKAQ KNYPHEQIVV KGYRGNVCQT  60
   61 EKGVKYLGTR LAEYIIQDLY DESIRKISFV GHSLGGLIQA FAIAYIYEVY PWFFKKVNPI 120
  121 NFITLASPLL GIVTDNPAYI KVLLSFGVIG KTGQDLGLEN DVEVGKPLLY LLSGLPLIEI 180
  181 LRRFKRRTVY ANAINDGIVP LYTASLLFLD YNDILEQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.045757
Match: 1hqdA_
Description: Lipase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
hydrolase activity 1.1444670166202 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.985235528680562 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [395-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKLKENSKKS PLINDASTPV NQDFFNKTFI SPLTKMLSIL APQKFPTENG SEIPKVSFFE  60
   61 SASSILLPPL PERAYIMDPD SRDPVIIHDK IYNEDDIPQS EFDIEDGFFG KKNILLQAFF 120
  121 AGKKERAKYR NLEETIARRW HEGMAWRKVV VALKPDAHNN IIVRRKFANA YGWPVIDHLI 180
  181 DVHFNGDDDD DNDENDDINS TQVVEPIQSV TEGKKKYRKA ENIPQEYGWL NKVETNGVFD 240
  241 EGPTGMISTV GEIVEALAKR GFSAVIDRRN ASEDPNDEVL RFEEMNSDLV Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [499-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDGFFGKKNI LLQAFFAGKK ERAKYRNLEE TIARRWHEGM AWRKVVVALK PDAHNNIIVR  60
   61 RKFANAYGWP VIDHLIDVHF NGDDDD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [585-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNDENDDINS TQVVEPIQSV TEGKKKYRKA ENIPQEYGWL NKVETNGVFD EGPTGMISTV  60
   61 GEIVEALAKR GFSAVIDRRN ASEDPNDEVL RFEEMNSDLV Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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