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Protein Overview: HPA3

General Information:
Name(s) found: HPA3 / YEL066W [SGD]
Description(s) found:
Found 23 descriptions.
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  • D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 179 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: histone acetylation [NASLink to PubMed article]
    Molecular Function: histone acetyltransferase activity [ISSLink to PubMed article][NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTPDPSPP FASTKNVGMS NEEPEKMVND RIVVKAIEPK DEEAWNKLWK EYQGFQKTVM  60
   61 PPEVATTTFA RFIDPTVKLW GALAFDTETG DAIGFAHYLN HLTSWHVEEV VYMNDLYVTE 120
  121 RARVKGVGRK LIEFVYSRAD ELGTPAVYWV TDHYNHRAQL LYTKVAYKTD KVLYKRNGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HPA3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179] PSI-BLAST 457.190949 Histone acetyltransferase HPA2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  6.09290029352595 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  5.99007195691126 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • acetyltransferase activity
    		•  4.88581443210764 bayes_pls_golite062009
    		• 3.31223878955144 bayes_pls_golite062009
  • transferase activity
    		•  2.87429355361226 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.48213335904382 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  2.37125669491841 bayes_pls_golite062009
  • acyltransferase activity
    		•  2.34144059663209 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • binding
    		•  1.07749536895426 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.952148883380044 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.952148883380044 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.522132859536345 bayes_pls_golite062009
  • protein binding
    		•  0.283213965640071 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0766125702622449 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle