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Protein Overview: TGL2

General Information:
Name(s) found: TGL2 / YDR058C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 326 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: lipid metabolic process [ISSLink to PubMed article]
    Molecular Function: triglyceride lipase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNDNKANDI IIDSVKVPDS YKPPKNPIVF CHGLSGFDKL ILIPSVFHLT NLISNSIVHN  60
   61 MAENFMQDDE DKSDNKYTNL LEIEYWIGVK KFLQSKGCTV ITTKVPGFGS IEERAMALDA 120
  121 QLQKEVKKIE SKDKRHSLNL IAHSMGGLDC RYLICNIKNR NYDILSLTTI STPHRGSEMA 180
  181 DYVVDLFENL NALRVSQKIL PICFYQLTTA YMKYFNLVTP NSPKVSYFSY GCSFVPKWYN 240
  241 VFCTPWKIVY ERSKGCPNDG LVTINSSKWG EYRGTLKDMD HLDVINWKNK LQDDWSKFFR 300
  301 TTTVGEKVDI LNFYLKITDD LARKGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) TGL2 URA10 URA5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231]
    [262..276]
    [310..326]    		 PSI-BLAST 175.24799 Lipase
    2 View Details [232..261]
    [277..309]    		 PSI-BLAST 175.24799 Lipase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • hydrolase activity
    		•  0.716449555827534 bayes_pls_golite062009
  • lipase activity
    		•  0.602417432627875 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.535924720022784 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.100880080935406 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle