Protein Overview: toy-PA

General Information:
Name(s) found:	toy-PA / FBpp0088249 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene twin of eyeless is referred to in FlyBase by the symbol Dmel\toy (CG11186, FBgn0019650). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1010354..1026929. It has the cytological map location 102F4-102F5. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: eye-antennal disc development. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye-antennal disc; leg; eye disc; antenna; wing; head. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	543 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA][NAS]
Biological Process:	regulation of transcription, DNA-dependent [IEA] regulation of transcription [IEA][NAS] eye-antennal disc development [IMP] compound eye development [TAS]
Molecular Function:	transcription factor activity [IEA] specific RNA polymerase II transcription factor activity [NAS] sequence-specific DNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLTTEHIMH GHPHSSVGQS TLFGCSTAGH SGINQLGGVY VNGRPLPDST RQKIVELAHS  60
   61 GARPCDISRI LQVSNGCVSK ILGRYYETGS IKPRAIGGSK PRVATTPVVQ KIADYKRECP 120
  121 SIFAWEIRDR LLSEQVCNSD NIPSVSSINR VLRNLASQKE QQAQQQNESV YEKLRMFNGQ 180
  181 TGGWAWYPSN TTTAHLTLPP AASVVTSPAN LSGQADRDDV QKRELQFSVE VSHTNSHDST 240
  241 SDGNSEHNSS GDEDSQMRLR LKRKLQRNRT SFSNEQIDSL EKEFERTHYP DVFARERLAD 300
  301 KIGLPEARIQ VWFSNRRAKW RREEKMRTQR RSADTVDGSG RTSTANNPSG TTASSSVATS 360
  361 NNSTPGIVNS AINVAERTSS ALVSNSLPEA SNGPTVLGGE ANTTHTSSES PPLQPAAPRL 420
  421 PLNSGFNTMY SSIPQPIATM AENYNSSLGS MTPSCLQQRD AYPYMFHDPL SLGSPYVSAH 480
  481 HRNTACNPSA AHQQPPQHGV YTNSSPMPSS NTGVISAGVS VPVQISTQNV SDLTGSNYWP 540
  541 RLQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..162]	PSI-BLAST	54.522879	Pax-5
2	View Details	[163..271]	deduced	N/A	No confident structure predictions are available.
3	View Details	[272..333]	PSI-BLAST	11.154902	Solution structure of the homeobox domain of the human paired box protein Pax-6
4	View Details	[334..543]	FFAS03	0.96	No description for 2j63A was found.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.51452285155271	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
sequence-specific DNA binding	3.5139760613123	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.16896789933192	bayes_pls_golite062009
transcription activator activity	3.10621734076555	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
transcription repressor activity	1.91962622287073	bayes_pls_golite062009
protein binding	1.88087411289001	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.73068440195944	bayes_pls_golite062009
chromatin binding	1.68956710349366	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
transcription corepressor activity	0.25931464844298	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.51452285155271	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
sequence-specific DNA binding	3.5139760613123	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.16896789933192	bayes_pls_golite062009
transcription activator activity	3.10621734076555	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
transcription repressor activity	1.91962622287073	bayes_pls_golite062009
protein binding	1.88087411289001	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.73068440195944	bayes_pls_golite062009
chromatin binding	1.68956710349366	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
transcription corepressor activity	0.25931464844298	bayes_pls_golite062009

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

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