Protein Overview: eIF4G-PA, eIF4G-PC

General Information:
Name(s) found:	eIF4G-PC / FBpp0288389 [FlyBase] eIF4G-PA / FBpp0088303 [FlyBase]
Description(s) found: SHOW ONLY BEST	pir\|\|T09072 probable translation initiation factor eIF-4 gamma - fruit fly (Drosophila melanogaster) [NCBI NR] gi\|3056723\|gb\|AAC38985.1\| translation initiation factor eIF4G [Drosophila melanogaster] [NCBI NR] gi\|221329589\|ref\|NP_001137857.1\| eukaryotic translation initiation factor 4G, isoform C [Drosophila melanogaster] [NCBI NR] gi\|220901630\|gb\|ACL82868.1\| eukaryotic translation initiation factor 4G, isoform C [Drosophila melanogaster] [NCBI NR] gi\|218505849\|gb\|ACK77586.1\| FI02056p [Drosophila melanogaster] [NCBI NR] gi\|161076325\|ref\|NP_524640.3\| eukaryotic translation initiation factor 4G, isoform A [Drosophila melanogaster] [NCBI NR] gi\|157400024\|gb\|AAF59403.3\| eukaryotic translation initiation factor 4G, isoform A [Drosophila melanogaster] [NCBI NR] The gene eukaryotic translation initiation factor 4G is referred to in FlyBase by the symbol Dmel\eIF4G (CG10811, FBgn0023213). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:935911..951347. It has the cytological map location 102F1. There is experimental evidence that it has the molecular function</span>: RNA 7-methylguanosine cap binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; G1/S transition of mitotic cell cycle; mitotic spindle organization. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] (O61380) EIF-4G protein [DrosMelano7227.FASTAC.txt] probable translation initiation factor eIF-4 gamma - fruit fly (Drosophila melanogaster)gi\|3056723\|gb\|AAC38985.1\| translation initiation factor eIF4G [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] (AE003846) eIF-4G gene product [Drosophila melanogaster] [yeastflysequest.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp00883 [fly-100309-contam.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp02883 [fly-100309-contam.fasta] translation initiation factor eIF4G [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Eukaryotic translation initiation factor 4G, isoform A OS=Drosophila melanogaster GN=eIF4G PE=1 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,950448..950525); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868,FlyMine:FBpp0288389,modMine:FBpp0288389; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Eukaryotic translation initiation factor 4G, isoform A OS=Drosophila melanogaster GN=eIF4G PE=2 SV=3 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868,FlyMine:FBpp0288389,modMine:FBpp0288389; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868,FlyMine:FBpp0288389,modMine:FBpp0288389; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A8DZ29, Eukaryotic translation initiation factor 4G, isoform A OS=Drosophila melanogaster GN=eIF4G PE=1 SV=3 [DROME.fasta.20160308] FBpp0088303 type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0088303; name=eIF4G-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0288389 type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0288389; name=eIF4G-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868,FlyMine:FBpp0288389,modMine:FBpp0288389; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0088303; name=eIF4G1-PA; parent=FBgn0023213,FBtr0089243; dbxref=FlyBase:FBpp0088303,FlyBase_Annotation_IDs:CG10811-PA,GB_protein:AAF59403.2,GB_protein:AAF59403,REFSEQ:NP_524640,GB_protein:AAF59403,UniProt/TrEMBL:O61380; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=4:complement(join(929822..929899,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0288389; name=eIF4G1-PC; parent=FBgn0023213,FBtr0289951; dbxref=FlyBase:FBpp0288389,FlyBase_Annotation_IDs:CG10811-PC,REFSEQ:NP_001137857,GB_protein:ACL82868,UniProt/TrEMBL:O61380,FlyMine:FBpp0288389,modMine:FBpp0288389; MD5=74663c1e955d602e94d30e74f4c099a4; length=1666; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1666 amino acids
Gene Ontology:
Cellular Component:	eukaryotic translation initiation factor 4F complex [ISS] cytosol [ISS]
Biological Process:	mitotic spindle elongation [IMP] RNA metabolic process [IEA] mitotic spindle organization [IMP] G1/S transition of mitotic cell cycle [IMP] translational initiation [ISS]
Molecular Function:	translation initiation factor activity [ISS] RNA 7-methylguanosine cap binding [IDA] protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQAIPTLPT QSDIDKAMQP HSAQNMYVST GNNNSGNTRS NPQSGGIFRG PPSTPNAPRG  60
   61 ASGGATRHVH VQPMYSQPLH QNMVLQQYTQ YNPRQQTFPA SHLQYAPAPM PYYQYQYVPT 120
  121 LQQQPPHTRS AVTVNTNVNV GNNLQPVQSG PNGPLPVPGA SSSQIQLLTS TVQPGASTVM 180
  181 GVGGPGSTMG QVGVPPMVGV GVMTTSVQPQ PVQVQPASRR RHQHRLQIID PTTKKNILDD 240
  241 FDKTKSNTDN EFSDQVTSTN TPATVLSEGP IRIPQQESVG LNNLTSTSSQ GSESRTNAPY 300
  301 IPIETTPISR TDVGPTPIVS AMTDAPSVEI LPTPQRGRSK KIPIVSPKNV SESIVAPITD 360
  361 ETDDAGSTPI SRATEESMPP NQTHPNLLIS DSSKHKQAVS NSEISKDAPT GLKEMHVAEL 420
  421 ESSVASENHP AGILDVNVNK SSQSLDFSAD PEIDSIGAIS PTSPNAVSPI LHEVLDNTEL 480
  481 SKKLENSTTE RFKDSQSVEK PTHQELSLRN ATDETEISAM ALQDVNSLDN NQIEKTYPSK 540
  541 PKLNVDVSED ISSRESAIKS TSTKNTGVDV GLQSDSKPET TLNDKQDSTD LKVKVSAKIS 600
  601 SIINYNEGQW SPNNPSGKKQ YDREQLLQLR EVKASRIQPE VKNVSILPQP NLMPSFIRNN 660
  661 NNNKRVQSMV GIIGNRSNES AGNYIGKQMS MSGVQSGGGR SSMKGMIHVN LSLNQDVKLS 720
  721 ENENAWRPRV LNKSDGDSDA KSALEKDELV RRVRGILNKL TPERFDTLVE EIIKLKIDTP 780
  781 DKVDEVIVLV FEKAIDEPNF SVSYARLCQR LAAEVKVIDE RMESETKSNS AHFRNALLDK 840
  841 TEQEFTQNVS QSTAKEKKLQ PIVDKIKKCT DANEKAELEA FLEEEERKIR RRSGGTVRFI 900
  901 GELFKISMLT GKIIYSCIDT LLNPHSEDML ECLCKLLTTV GAKFEKTPVN SKDPSRCYSL 960
  961 EKSITRMQAI ASKTDKDGAR VSSRVRFMLQ DVIDLRKNKW QTSRNEAPKT MGQIEKEAKN1020
 1021 EQLSAQYFGT LSSTTPGGSQ GGSGKRDDRG NSRYGESRSS SAYGGSHSQR GDNGNLRHQQ1080
 1081 QNNVGGNVSG GAGHSNGNND ENTWHVQTSK GSRSLAVDSN KLEGLSKLSD QNLETKKMGG1140
 1141 LTQFIWISSD TTRLSSAPTP TPSNPFAVLS SLIDKNSNER DRDRSGPRNK GSYNKGSMER1200
 1201 DRYDRGMHSR TGSSQGSREN SSSRGGQQGR TLLSSSVQKS TSHSKYTQQA PPTRHTVKAQ1260
 1261 SSVGSSNVNT GPLYRGSEQQ TSATFSQTTR SVAPVAVFIE ASETDLKLIK SVVSEIVDLS1320
 1321 AASKEVTPGA VSCIKRVPEK LRCSFIYYIL TDYLHLANVG KQYRRYLSIA VSQLIQQNYI1380
 1381 SADHLRLAYN EFTVYANDLI VDIPELWLYI LQFAGPLIVK KILTISDLWN NNLKENSPSN1440
 1441 VAKKFLKTYL IYCTQEVGPN FARNMWIKFN LKWSDFMPES EVADFIKFNR LEYVENESKS1500
 1501 PVIDHRETPE KHVKNVIDHI EHLLKEGTTA DCIIDYSNGN IMVVDKLFIR GLTETLSNFS1560
 1561 IHYKDNSYKL ESETFQKFCI PVLQRYIDSN EDHQLECLYT LQLLVHGLEH PRGLLSELIG1620
 1621 ELYDAFVIQK ESLCKWRDSK DQSAGKGVAV KSLNPFFNSL LNDDAN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: eIF4G-PA, eIF4G-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: