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Protein Overview: nas-37

General Information:
Name(s) found: nas-37 / CE31417 [WormBase]
Description(s) found:
Found 20 descriptions.
SHOW ALL
  • WBGene00003553 locus:nas-37 Zinc metalloproteinase nas-37 status:Partially_confirmed UniProt:Q93243 protein_id:CAB01675.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 765 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    extracellular region [IDALink to PubMed article]
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed article]
    molting cycle, protein-based cuticle [IMPLink to PubMed articleLink to PubMed article]
    collagen and cuticulin-based cuticle development [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    ecdysis, collagen and cuticulin-based cuticle [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [ISSLink to PubMed article]
    protein binding [ISSLink to PubMed article]
    astacin activity [IDALink to PubMed article][IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSQACLKVC LALIGLVSIV STAYIANDVV SDYAEVKELL AAFYRKHAKK YGHDYDPAAI  60
   61 QAIAENMDKS VKNDKTEATV NRKLWNEVFE NDIILTLPQA ESLLSESNSP RSRRQAHPDP 120
  121 RNFWPNLTIS YEFYGGEETW RQLIRSAIRH VEQNVCFKFK ENGGDRDGLR YYRGNGCWSN 180
  181 VGRVGGRQLV SIGYGCDSLG IVSHETLHAL GLWHEQSRDD RDNFISIVAD KITRGTEGNF 240
  241 AKRTAANSDN LGQPYDLGSV MHYGAKSFAY DWSSDTIKTR DWRYQNTIGQ RDGLSFKDAK 300
  301 MINTRYCSNV CQRSLPCLNE GYTDPNNCGR CRCPSGYGGT YCETVEYTSC GGSLTASSSY 360
  361 KKIESGIVQP DANCVWRIRN PGGNVEVMFD QVNFQCADPC QSYVEVKYLS QKTSTGARLC 420
  421 CSLPSVIRSE GDDVIIILRG TPNTAVGWRG FTLKYRAIGG TPITPATVRP TYATTTRPYW 480
  481 TRTASGWIHI KNPPLYKPDG QIYTSDEQSA ETKYSSEELY DPSTFLSPSS SSASPALLLP 540
  541 SDASPQRPSA QEHDLSQLSQ NALTRPTPTT TVAPDTASWS AWGEWSACSQ PCGGCGTKTR 600
  601 VRACYGGNQV CPGSNLDRES CNAHACAKPK KGMICNGRLL LPCDLLAKLN FGSNNYLNPK 660
  661 LKQSGFARSS TLPLPRISQR KPVFVNELEV HPPTERFLSS STRRVKRQTA NRFCEKRFIY 720
  721 QCPTALLTIQ MEYKPDTQGT NDAYFQQYPE CCSGYTPRRG VCYKN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] deduced N/A No confident structure predictions are available.
    2 View Details [74..193] PSI-BLAST 48.0 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [194..307] PSI-BLAST 4.30103 No description for 2dw0A was found.
    4 View Details [308..683] PSI-BLAST 5.221849 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    5 View Details [684..765] PSI-BLAST 12.69897 Solution structure of dimeric form of properdin by X-ray solution scattering and analytical ultracentrifugation

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • ErbB-2 class receptor binding
    		•  2.43291483229075 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.14752073450101 bayes_pls_golite062009
  • binding
    		•  2.14092582858845 bayes_pls_golite062009
  • protein binding
    		•  1.87564165872234 bayes_pls_golite062009
  • receptor binding
    		•  1.84697876356356 bayes_pls_golite062009
  • transcription factor binding
    		•  0.89765738417424 bayes_pls_golite062009
  • signal transducer activity
    		•  0.673391983395207 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.673391983395207 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.49319143757878 bayes_pls_golite062009
  • growth factor activity
    		•  0.473340802107115 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.225989825753998 bayes_pls_golite062009
  • pattern binding
    		•  0.0196006376432096 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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