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Protein Overview: daf-8

General Information:
Name(s) found: daf-8 / CE06236 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00000904 locus:daf-8 status:Partially_confirmed UniProt:Q21733 protein_id:CAA99889.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: dauer larval development [IGILink to PubMed article][IMPLink to PubMed article]
    oviposition [IGILink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    pigment accumulation [IGILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDFPSPEPT DPRLEAMAQK VLEETIITEG DGTIYWALKV TRLLSRVAKK HQCFEAFYDA  60
   61 VIKGDPKTRC CPAHNEKLIG NFGRAIMCVL RAFRFPVIRY ESQVKSILTC RHAFNSHSRN 120
  121 VCLNPYHYRW VELPTCQVPP IIVNKELDYG EPPIRTEDAL DDWNQKDLKE EQVVASWDVP 180
  181 NVTMRGDEIK LLYDRYAAEN GDFQYMNYGN FGSFDGSPCS STTMSLGSSF ASLLQQSNRQ 240
  241 DDEEPGYYRS GLSSPASHAA SPREFIPNGN DTISLDQEMM DDSEVSDIMH SENFSSENNG 300
  301 NRKPTYADGR PITPIEPRPL YRSSALELGD LSRQAGIYEC VEYEESPSWL KLIYYEEGTM 360
  361 IGEKADVEGH HCLIDGFTAS RTDSETRSRF SLGWYNNPNR SPQTAEVRGL IGKGVRFYLL 420
  421 AGEVYVENLC NIPVFVQSIG ANMKNGFQLN TVSKLPPTGT MKVFDMRLFS KQLRTAAEKT 480
  481 YQDVYCLSRM CTVRVSFCKG WGEHYRRSTV LRSPVWFQAH LNNPMHWVDS VLTCMGAPPR 540
  541 ICSSRT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] PSI-BLAST 43.69897 SMAD MH1 domain
    2 View Details [134..316] PSI-BLAST 5.0 Sec24
    3 View Details [317..546] PSI-BLAST 87.221849 Smad1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein binding
    		•  2.72705938702913 bayes_pls_golite062009
  • binding
    		•  2.31656652567204 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.93348471274042 bayes_pls_golite062009
  • DNA binding
    		•  1.64107635602436 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59899290578262 bayes_pls_golite062009
  • transcription activator activity
    		•  1.1056197205863 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.93638089729878 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  0.70979718281225 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.59091508757448 bayes_pls_golite062009
  • transcription factor activity
    		•  0.554078523633227 bayes_pls_golite062009
  • signal transducer activity
    		•  0.29313054064574 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.29313054064574 bayes_pls_golite062009
  • catalytic activity
    		•  0.257477082550163 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  0.17825540288715 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  0.0594594490862095 bayes_pls_golite062009
  • SMAD binding
    		•  0.0361094043816896 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0268350196675502 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle