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Protein Overview: hst2

General Information:
Name(s) found: hst2 / SPCC132.02 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • Sir2 family histone deacetylase Hst2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 332 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    telomeric heterochromatin [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    rDNA heterochromatin [IDALink to PubMed article]
    chromatin remodeling complex [ISSLink to PubMed article]
    centromeric heterochromatin [IDALink to PubMed article]
    Biological Process: chromatin remodeling [ISSLink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    histone deacetylation [TASLink to PubMed article]
    regulation of nucleosome density [IEPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    transcription corepressor activity [IEPLink to PubMed article]
    transcription regulator activity [ICLink to PubMed article]
    NAD or NADH binding [IEA]
    NAD-dependent histone deacetylase activity [TASLink to PubMed article]
    specific transcriptional repressor activity [IEPLink to PubMed article]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKNTVKHVD SSKHLEKVAS LIKEGKVKKI CVMVGAGIST AAGIPDFRSP ETGIYNNLQR  60
   61 FNLPYAEAVF DLSYFRKNPR PFYELAHELM PEKYRPTYTH YFIRLLHDKR LLQKCYTQNI 120
  121 DTLERLAGVP DKALIEAHGS FQYSRCIECY EMAETEYVRA CIMQKQVPKC NSCKGLIKPM 180
  181 IVFYGEGLPM RFFEHMEKDT KVCDMALVIG TSLLVHPFAD LPEIVPNKCQ RVLINREPAG 240
  241 DFGERKKDIM ILGDCDSQVR ALCKLLGWSD ELEKLIDTSV ETLTEEISLL SVDSTIEKNA 300
  301 SEQKKDDNSV NPFTKIEEKK KDEVTLLVSD DE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] PSI-BLAST 83.0 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  4.51070381823692 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  2.82468859281133 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  1.11434618720209 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle