Protein Overview: SPBC1685.05

General Information:
Name(s) found:	SPBC1685.05 [Sanger Pombe]
Description(s) found: Found 17 descriptions. SHOW ALL	serine protease [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	997 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA]
Biological Process:	proteolysis [ISS] proteolysis involved in cellular protein catabolic process [NAS]
Molecular Function:	serine-type endopeptidase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPVSSDYRP NHIFLPKFRP DKITSECNTP QQQNVIAEGL YNVSEPFPIR NTDEERYLDT  60
   61 KEIHHTWDNT IKNVVRSIVS IKGSALRSFD TESAGSFCAT GFVVNKTLGL ILSNRHVVSP 120
  121 GPISARASFI NYEEIDIYPI YRDPVHDFGF FRYDPSSIRF HDVTEISLSP ESAKVGIDIR 180
  181 IIGNDAGEKL SILSSTLARL DRPAPNYGID NYNDFNTFYY QAASGTSGGS SGSPVLDISG 240
  241 AAVALNSGGS NSSASSFYLP LDRVVRALRC IENNTPITRG TLLTEFLHWS YDELSRIGLP 300
  301 REFEYDCRTR VPSSTGLLVV SRVLRNSEVS KALEPGDILI AFKTDSHKST YIVDFVSLFE 360
  361 VLDEMVGKTI ELHVYRPKRG FLTFQLTVQD LHNVTPSRFL EVGGAVLHDL SYQLARSYQF 420
  421 SLNSGTYVAS SGMLNWSSGT RDFLVTRLAN KPTPTLDAFI DVLVQLTDNA RVPMHFRVLG 480
  481 KYEEEFTIVT VDRHFFLASI FSRNDEKGTW DRQSLPPPQP SISRRPSVIP RPQEGSKSME 540
  541 AIQNALVLVH CRMPYSINGF SSTKLYSGTG VIVSVVPPLI VVDRSVIPVD ICDIRLTFQS 600
  601 MSAMGHLTFL DNRIAVVSCD YLPSNSVQLN FVADFLRTGD ECTLAALDED LQLLTKKTTV 660
  661 RSVSVVETER SSPPRFRYVN CEVISLMDSL ASTGGLVFRE VGDDREIVAL WISVVHQDVG 720
  721 GKDYTTKYGL SMSYILPVLE RLKLPPSARA QHVPTTAGVE WSHITLAGAS TLGLSQTRSS 780
  781 EFYMKSRENG TIPRPLYVIS HLRPLLHKTS LGVGDILLEV NGKMITRLSD LHEFETESEI 840
  841 KAVILRDGIE MEITIPLYPE YPTFSSRAIC WMGAIIHPTH SSVFEQVEPD VDLPGPEGVY 900
  901 VGSILYGSPA LNMLRAAHWI VAVDGHDINT FDDFYHMLLE KPTDTFVQVK QMNRRGATSI 960
  961 VSVRPDPLFW PTCIIERDSN GRWCTKHLQR KTKEVCS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..62]	MSA	1.324996	View MSA. No confident structure predictions are available.
2	View Details	[63..395]	PSI-BLAST	39.69897	Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form
3	View Details	[396..493]	PSI-BLAST	6.0	Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins
4	View Details	[494..997]	PSI-BLAST	73.522879	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

3

No functions predicted.

4

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
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