Protein Overview: SPAC23G3.12c

General Information:
Name(s) found:	SPAC23G3.12c [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	serine protease [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	996 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	lipid metabolic process [ISS] proteolysis involved in cellular protein catabolic process [NAS]
Molecular Function:	serine-type endopeptidase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIKKRARAG SKSDDIGNKT PKKNGIEHEA TKSSETVIEM TPSGPIAESK KWKESIARVV  60
   61 KSVVSIRFSQ VAAFDTDESG TGEASAFVVD AKNGYMLTNR HVVCAGPFVG HAVFDNHEEV 120
  121 EVFPVYRDPV HDFGFLRFDP KKIRYMNVEQ LELRPDLAKV GTEIRVVGND AAEKLSILAG 180
  181 WISRIDRNVP DYGELTYCDF NTNYIQAAAN ASGGSSGSPV VERNGNVVAL QAGGHMIAAT 240
  241 DYFLPLDRPL RALRCLQNNT PITRGTIQAQ FLIKTFDECS RLGLDSAMEE KVRTLFPEAT 300
  301 SMLVVETVLP EGPSFKKLKE GDILLYVNSM ILINLIELES ILDESVGKDV VLTVQRGSEL 360
  361 VELTCTAQST HDIAPDRYVE VCGAKFHNLS YQLARQYALP VKGVFISEPA GSFRLEGPEY 420
  421 GYILDSIAYK PVPDLDTFIE VMRDIPDRSR VAVGYHFIHD KHSLITDVVE IDRHWLKAFR 480
  481 MVTRNDETGL WDFKNLGDPL PAEPSKPCTT SIPKLNVENF GPTANIINCF VKVLYYMPLH 540
  541 LDGSRKSRKK GTALVLDKDK GLAVTSRSTV PYDLGDLTIT VADSIQIPAE VVHLHPTQNL 600
  601 AFIKYDPKLL GDTPIQAAKL KDYYVSQGDP VNFFGFNSKS RVVAAKTSVT DVITMVIPSS 660
  661 PMPRFRAINF ESITVESNLS TQCGSGVLTD DDGLVVALWL THYGEQTSRG TDVKYHLGLA 720
  721 SPVVLSTLRR LQSGVNVNPR ILNVEFRAIQ LAQARSLGLP AERIRKIETE SGKKHQLFMI 780
  781 THVEAGTPRI LTDGDIIISA NGKSITRIRD LQVDDVTEVD MEILREGKVQ TVKVPTFPSD 840
  841 NCETNRVVIC WGATLQAPHR AVRLQIEDLP SNVFVTNRGR GSPADQYDLG AAQFITAVNG 900
  901 VTTLNLEDFV REIRKIDDNS YVRVSTSTFD KVPVVLTIKM NKHYFPTIDL VQDAKAENGW 960
  961 RAVQYDEVGE KKNPSMGFTI DEEVDDNTFD TEGEQQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..374]	PSI-BLAST	48.30103	Crystal Structure of DegS protease in complex with an activating peptide
2	View Details	[375..475]	PSI-BLAST	6.69897	Photosystem II D1 C-terminal processing protease
3	View Details	[476..996]	PSI-BLAST	72.69897	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

2

Term	Confidence	Notes
protein binding	3.43316749555592	bayes_pls_golite062009
binding	2.66667167586056	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
hydrolase activity	0.167877702757621	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

3

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle