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Protein Overview: DAAM-PA

General Information:
Name(s) found: DAAM-PA / FBpp0070231 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Dishevelled Associated Activator of Morphogenesis is referred to in FlyBase by the symbol Dmel\DAAM (CG14622, FBgn0025641). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1183740..1216389. It has the cytological map location 1F2-1F3. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: actin filament bundle formation; regulation of tube architecture, open tracheal system; open tracheal system development. 18 alleles are reported. The phenotypes of these alleles are annotated with: taenidial fold; filamentous actin; larval trachea; larval cuticle; larval tracheal system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1114 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of tube architecture, open tracheal system [IMP]
    actin cytoskeleton organization [NAS]
    cuticle pattern formation [NAS]
    actin filament bundle assembly [IMP]
    open tracheal system development [IMP]
    Molecular Function: actin binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSVDELDTK FAELVEELDL TAPNKEAMLS LPAQKKWQIY CSRKLPLDAA DGPDAAAVTQ  60
   61 PPTAEHYIER LKELVVHISL SPEDSPSHEL GNRLDGHAAF VDALKTALRT STHSFVLRFV 120
  121 ELDGLPALLD LLLQLDIRVA NSPLHTSLIG CIKALMNNSM GRAHVLAHPT AIDTIARSLA 180
  181 ADNIRTKIAA LEILGAVCLV PGGHRKVLQA MLHFQVFATE RTRFQSIVND LDRSTYAYRD 240
  241 NVNLKTALMS FVNAVLNYGP GQENLEFRLH LRYEFLMLGI QPVIDKLRTH ENETLDRHLD 300
  301 FFEMVRAEDE KEFARRFKEE HVDTKSAGSM FELLRRKLSH SPAYPHMLSL LQHMLLLPYT 360
  361 GHCTEHWLLI DRVVQQIVLQ VEQRPNSDLI VDPDDPEKQL KLAAESPVHD PDVAPLQIDV 420
  421 AKLVRLLVKE EQLTQARKRA DELERENFDV QSRLAKKEQE LDLRMQEKED LETGLARMRE 480
  481 RLEKESAQHS QAVQRAQTAE MRAEDLQHRL ISEQQERARL ERLVTEGSIP DDQKVAGLTG 540
  541 CNGAVSPPPA PPMLKAIPPP PPPMAPSMMP PPPPPCPGAP PPPPSMAQTM APAPPKVDLP 600
  601 KKNVPQPTNP LKSFNWSKLP DAKLQGTVWS ELDESKLYNN MELESIDKLF SAYQKNGVSA 660
  661 TDGSYEDLRV TGKAAKQKVL SVIDGRRAQN CTILLSKLKM SDMEISKAIL SMDSNEQLQL 720
  721 DMVEQLLKFT PSAEERALLD EHSEDIESLA RADRFLYEIS KIPHYEQRLK SLHYKKRFML 780
  781 TINDLVPRIT SVMEASREVA RSRRLRKLLE LVLALGNYMN RGARGNASGF RLASLNRLAD 840
  841 TKSSAAKGTT LLHYLVQVIE RKFKDLLKLE DDIPHVREAS KVSLGEMDKD IQMLRTGLAD 900
  901 VAREIEFHRS SGPAQQGDRF LPVMREFHAQ ASVRFAELED KFQDMKTRFD RAVRLFGEDG 960
  961 SVLQPDEFFG IFDSFLAAFA EARHDNESFR RRQEEEEKRA KQEAELKKRT IERKNKTGLM1020
 1021 TSVARNLGLK SGSSNGDPDS PAKGGDNKGE FDDLISALRT GDVFGEDMAK FKRSRKARVL1080
 1081 NGGGSSTGHT SPPRHGSLQR EESGRERERT VRRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..391] PSI-BLAST 73.39794 Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
    2 View Details [392..492] PSI-BLAST 63.0 Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1
    3 View Details [493..600] FFAS03 0.961 Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
    4 View Details [601..1114] PSI-BLAST 100.0 No description for 2j1dG was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.52869107451293 bayes_pls_golite062009
  • protein binding
    		•  0.91858015757355 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle