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Protein Overview: CG11837-PA

General Information:
Name(s) found: CG11837-PA / FBpp0084729 [FlyBase]
Description(s) found:
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  • gi|7301735|gb|AAF56847.1| CG11837 [Drosophila melanogaster] [NCBI NR]
  • gi|27151493|sp|Q9VAQ5.1|DIMT1_DROME RecName: Full=Probable dimethyladenosine transferase; AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; AltName: Full=18S rRNA dimethylase [NCBI NR]
  • gi|21358017|ref|NP_651660.1| CG11837 [Drosophila melanogaster] [NCBI NR]
  • gi|16769516|gb|AAL28977.1| LD35950p [Drosophila melanogaster] [NCBI NR]
  • Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 [Swiss-Prot]
  • (Q9VAQ5) Probable dimethyladenosine transferase (EC 2.1.1.-) (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [Swiss-Prot]
  • This gene is referred to in FlyBase by the symbol Dmel\CG11837 (CG11837, FBgn0039627). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24875233..24876443. It has the cytological map location 98F6. Based on sequence similarity, it is predicted to have molecular function</span>: rRNA (adenine-N6,N6-)-dimethyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: rRNA modification. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG11837-PA translation from_gene[CG11837 CG11837 FBgn0039627] seq_release:3 mol_weight=35049 cds_boundaries:(3R:24,864,688..24,865,731[+]) aa_length:306 transcript_info:[CG11837-RA seq_release:3] gene_info:[gene symbol:CG11837 FBgn0039627 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003768) CG11837 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG11837-PA [Drosophila melanogaster]gi|16769516|gb|AAL28977.1| LD35950p [Drosophila melanogaster]gi|21358017|ref|NP_651660.1| CG11837-PA [Drosophila melanogaster]gi|27151493|sp|Q9VAQ5|DIMH_DROME Probable dimethyladenosine transferase (S-adenosylmethion [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(24875322..24875379,24875442..24876154,24876219..24876368); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_pr [fly-100309-contam.fasta]
  • CG11837-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD35950p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(24875322..24875379,24875442..24876154,24876219..24876368); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(24875322..24875379,24875442..24876154,24876219..24876368); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(24875322..24875379,24875442..24876154,24876219..24876368); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847,FlyMine:FBpp0084729,modMine:FBpp0084729; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(29049600..29049657,29049720..29050432,29050497..29050646); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847,FlyMine:FBpp0084729,modMine:FBpp0084729; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(29049600..29049657,29049720..29050432,29050497..29050646); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847,FlyMine:FBpp0084729,modMine:FBpp0084729; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0084729 type=protein; loc=3R:join(29049600..29049657,29049720..29050432,29050497..29050646); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847,FlyMine:FBpp0084729,modMine:FBpp0084729; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(29049600..29049657,29049720..29050432,29050497..29050646); ID=FBpp0084729; name=CG11837-PA; parent=FBgn0039627,FBtr0085360; dbxref=FlyBase:FBpp0084729,FlyBase_Annotation_IDs:CG11837-PA,GB_protein:AAF56847.1,REFSEQ:NP_651660,GB_protein:AAF56847,UniProt/Swiss-Prot:Q9VAQ5,FlyMine:FBpp0084729,modMine:FBpp0084729; MD5=bad9377e577f5052b392536905c4b16e; length=306; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 306 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: rRNA modification [ISS]
    Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKVTKEKKS RIHNDVQKQG IVFNKDFGQH ILKNPLVITT MLEKAALRAT DVVLEIGPGT  60
   61 GNMTVRMLER AKKVIACEID TRLAAELQKR VQATPLQPKL QVLIGDFLKA ELPFFDLCIA 120
  121 NVPYQISSPL IFKLLLHRPL FRCAVLMFQR EFAERLVAKP GDKLYCRLSI NTQLLARVDM 180
  181 LMKVGKNNFR PPPKVESSVV RLEPKNPPPP VNFTEWDGLT RIAFLRKNKT LAATFKVTSV 240
  241 LEMLEKNYKL YRSLRNEPIE DDFKMQDKVI SILEEQDMAA KRARSMDIDD FMRLLLAFNS 300
  301 AGIHFN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..306] PSI-BLAST 68.39794 Crystal structure of human Dimethyladenosine transferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.00768472859991 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.57681394097837 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.49392219433935 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  2.00108769169811 bayes_pls_golite062009
  • RNA binding
    		•  1.99752836873461 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.76571145896453 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.94499223839747 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.90544396691236 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • binding
    		•  0.777596419415505 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.742142092552002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • mRNA binding
    		•  0.0540207721800283 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.0408000230099101 bayes_pls_golite062009
  • snoRNA binding
    		•  0.00848192089639488 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle