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Protein Overview: HLHmbeta-PA

General Information:
Name(s) found: HLHmbeta-PA / FBpp0084355 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene E(spl) region transcript mÃ?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\HLHmÃ?&#142;Ã?² (CG14548, FBgn0002733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21830648..21831745. It has the cytological map location 96F9. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: negative regulation of transcription from RNA polymerase II promoter. 7 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; wing margin bristle; macrochaeta; anterior crossvein; scutellar bristle; microchaeta; wing vein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 195 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA][NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [ISS]
    Notch signaling pathway [NAS]
    negative regulation of transcription [NAS]
    nervous system development [NAS]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA]
    compound eye development [TAS]
    Molecular Function: DNA binding [ISS][NAS]
    transcription factor activity [TAS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [ISS]
    specific transcriptional repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLEMEMSKT YQYRKVMKPM LERKRRARIN KCLDELKDIM VECLTQEGEH ITRLEKADIL  60
   61 ELTVEHMKKL RAQKQLRLSS VTGGVSPSAD PKLSIAESFR AGYVHAANEV SKTLAAVPGV 120
  121 SVDLGTQLMS HLGHRLNYLQ VVVPSLPIGV PLQAPVEDQA MVTPPPSECD SLESGACSPA 180
  181 PSEASSTSGP MWRPW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] PSI-BLAST 12.045757 Myc prot-oncogene protein
    2 View Details [78..195] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.58751248599889 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.31910036997977 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.03674713048499 bayes_pls_golite062009
  • protein binding
    		•  1.59929864805879 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle