YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: eve-PA

General Information:
Name(s) found: eve-PA / FBpp0087478 [FlyBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • The gene even skipped is referred to in FlyBase by the symbol Dmel\eve (CG2328, FBgn0000606). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5866746..5868284. It has the cytological map location 46C10. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; transcription repressor activity. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; regulation of axonogenesis; negative regulation of cardioblast cell fate specification; germ-band extension; cephalic furrow formation; negative regulation of transcription, DNA-dependent. 129 alleles are reported. The phenotypes of these alleles are annotated with 47 unique terms, many of which group under: organ system; multi-cell-component structure; hypodermal muscle of larval abdomen; embryonic nervous system; embryonic neuron; peripheral nervous system; anatomical structure; nervous system; cuticle; ectoderm derivative. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: posterior head segmentation [TAS]
    anterior/posterior axis specification, embryo [NAS]
    motor axon guidance [IMP]
    blastoderm segmentation [TAS]
    periodic partitioning by pair rule gene [NAS][TAS]
    nervous system development [NAS]
    germ-band extension [IMP][TAS]
    regulation of transcription, DNA-dependent [IEA][ISS]
    trunk segmentation [TAS]
    cephalic furrow formation [IMP]
    negative regulation of cardioblast cell fate specification [IMP]
    muscle organ development [TAS]
    heart development [NAS]
    central nervous system development [NAS]
    negative regulation of transcription, DNA-dependent [IDA]
    regulation of axonogenesis [IMP]
    cell fate commitment [NAS]
    cell fate determination [NAS]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGYRTYNME SHHAHHDASP VDQKPLVVDL LATQYGKPQT PPPSPNECLS SPDNSLNGSR  60
   61 GSEIPADPSV RRYRTAFTRD QLGRLEKEFY KENYVSRPRR CELAAQLNLP ESTIKVWFQN 120
  121 RRMKDKRQRI AVAWPYAAVY SDPAFAASIL QAAANSVGMP YPPYAPAAAA AAAAAAAVAT 180
  181 NPMMATGMPP MGMPQMPTMQ MPGHSGHAGH PSPYGQYRYT PYHIPARPAP PHPAGPHMHH 240
  241 PHMMGSSATG SSYSAGAAGL LGALPSATCY TGLGVGVPKT QTPPLDLQSS SSPHSSTLSL 300
  301 SPVGSDHAKV FDRSPVAQSA PSVPAPAPLT TTSPLPAPGL LMPSAKRPAS DMSPPPTTTV 360
  361 IAEPKPKLFK PYKTEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 14.39794 Even-skipped homeodomain
    2 View Details [136..303] FFAS03 1.12 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    3 View Details [304..376] FFAS03 1.09 Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle