Protein Overview: FBpp0307466, Pka...

General Information:
Name(s) found:	FBpp0307466 [FlyBase] Pka-C1-PC / FBpp0089382 [FlyBase] Pka-C1-PB / FBpp0079448 [FlyBase]
Description(s) found: SHOW ONLY BEST	pir\|\|C31751 protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain - fruit fly (Drosophila melanogaster) [NCBI NR] gi\|7807\|emb\|CAA34840.1\| catalytic subunit [Drosophila melanogaster] [NCBI NR] gi\|7297542\|gb\|AAF52797.1\| cAMP-dependent protein kinase 1, isoform A [Drosophila melanogaster] [NCBI NR] gi\|45552299\|ref\|NP_995672.1\| cAMP-dependent protein kinase 1, isoform C [Drosophila melanogaster] [NCBI NR] gi\|45445067\|gb\|AAS64669.1\| cAMP-dependent protein kinase 1, isoform C [Drosophila melanogaster] [NCBI NR] gi\|24583100\|ref\|NP_723479.1\| cAMP-dependent protein kinase 1, isoform B [Drosophila melanogaster] [NCBI NR] gi\|22946048\|gb\|AAN10703.1\| cAMP-dependent protein kinase 1, isoform B [Drosophila melanogaster] [NCBI NR] gi\|17862186\|gb\|AAL39570.1\| LD13640p [Drosophila melanogaster] [NCBI NR] gi\|17136902\|ref\|NP_476977.1\| cAMP-dependent protein kinase 1, isoform A [Drosophila melanogaster] [NCBI NR] gi\|157052\|gb\|AAA28412.1\| cAMP-dependent protein kinase catalytic subunit [NCBI NR] gi\|125215\|sp\|P12370.3\|KAPC_DROME RecName: Full=cAMP-dependent protein kinase catalytic subunit; Short=PKA C [NCBI NR] cAMP-dependent protein kinase catalytic subunit OS=Drosophila melanogaster GN=Pka-C1 PE=1 SV=3 [Swiss-Prot] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0307466; name=Pka-C1-PD; parent=FBgn0000273,FBtr0335495; dbxref=REFSEQ:NP_476977,GB_protein:AAF52797,FlyBase:FBpp0307466,FlyBase_Annotation_IDs:CG4379-PD; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.56; species=Dmel; [FlyBase] The gene cAMP-dependent protein kinase 1 is referred to in FlyBase by the symbol Dmel\Pka-C1 (CG4379, FBgn0000273). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:9684656..9699293. It has the cytological map location 30C5. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; regulation of developmental process; anatomical structure development; regulation of cell morphogenesis; organ development; regulation of biological process; oocyte axis specification; regulation of cellular component organization; regulation of molecular function; learning or memory; sleep. 85 alleles are reported. The phenotypes of these alleles are annotated with 31 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; external compound sense organ; female germline cyst; nervous system; adult mesothoracic segment; imaginal precursor; thoracic segment; egg; dorsal thoracic disc; morphogenetic furrow; antennal segment; neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] >CG4379-PB translation from_gene[CG4379 Pka-C1 FBgn0000273] seq_release:3 mol_weight=40839 cds_boundaries:(2L:9,688,737..9,689,795[-]) aa_length:353 transcript_info:[CG4379-RB seq_release:3] gene_info:[gene symbol:Pka-C1 FBgn0000273 gene_boundaries:(2L [hmr_yeast5_DM3-1_pombe.fasta] >CG4379-PA translation from_gene[CG4379 Pka-C1 FBgn0000273] seq_release:3 mol_weight=40839 cds_boundaries:(2L:9,688,737..9,689,795[-]) aa_length:353 transcript_info:[CG4379-RA seq_release:3] gene_info:[gene symbol:Pka-C1 FBgn0000273 gene_boundaries:(2L [hmr_yeast5_DM3-1_pombe.fasta] (AE003625) Pka-C1 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG4379-PC, isoform C [Drosophila melanogaster]gi\|22946048\|gb\|AAN10703.1\| CG4379-PB, isoform B [Drosophila melanogaster]gi\|7297542\|gb\|AAF52797.1\| CG4379-PA, isoform A [Drosophila melanogaster]gi\|54644691\|gb\|EAL33431.1\| GA18145-PA [Drosophila pseudoobscu [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079447; name=Pka-C1-PA; parent=FBgn0000273,FBtr0079850; dbxref=FlyBase:FBpp0079447,FlyBase_Annotation_IDs:CG4379-PA,GB_protein:AAF52797.1,REFSEQ:NP_476977,GB_protein:AAF52797; MD5=dc5e07cc21ab1161 [fly-100309-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703; MD5=dc5e07cc21ab1161 [fly-100309-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161 [fly-100309-contam.fasta] cAMP-dependent protein kinase 1 CG4379-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] cAMP-dependent protein kinase 1 CG4379-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] cAMP-dependent protein kinase catalytic subunit (PKA C) [nr-271106-contam.fasta] cAMP-dependent protein kinase 1 CG4379-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] LD13640p [Drosophila melanogaster] [nr-271106-contam.fasta] CG4379-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] cAMP-dependent protein kinase catalytic subunit [nr-271106-contam.fasta] catalytic subunit [Drosophila melanogaster] [nr-271106-contam.fasta] CG4379-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CG4379-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079447; name=Pka-C1-PA; parent=FBgn0000273,FBtr0079850; dbxref=FlyBase:FBpp0079447,FlyBase_Annotation_IDs:CG4379-PA,GB_protein:AAF52797.1,REFSEQ:NP_476977,GB_protein:AAF52797; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079447; name=Pka-C1-PA; parent=FBgn0000273,FBtr0079850; dbxref=FlyBase:FBpp0079447,FlyBase_Annotation_IDs:CG4379-PA,GB_protein:AAF52797.1,REFSEQ:NP_476977,GB_protein:AAF52797; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703,FlyMine:FBpp0079448,modMine:FBpp0079448; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703,FlyMine:FBpp0079448,modMine:FBpp0079448; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0307466; name=Pka-C1-PD; parent=FBgn0000273,FBtr0335495; dbxref=REFSEQ:NP_476977,GB_protein:AAF52797,FlyBase:FBpp0307466,FlyBase_Annotation_IDs:CG4379-PD; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703,FlyMine:FBpp0079448,modMine:FBpp0079448; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0307466; name=Pka-C1-PD; parent=FBgn0000273,FBtr0335495; dbxref=REFSEQ:NP_476977,GB_protein:AAF52797,FlyBase:FBpp0307466,FlyBase_Annotation_IDs:CG4379-PD; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0079448 type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703,FlyMine:FBpp0079448,modMine:FBpp0079448; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0089382 type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0307466 type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0307466; name=Pka-C1-PD; parent=FBgn0000273,FBtr0335495; dbxref=REFSEQ:NP_476977,GB_protein:AAF52797,FlyBase:FBpp0307466,FlyBase_Annotation_IDs:CG4379-PD; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0079448; name=Pka-C1-PB; parent=FBgn0000273,FBtr0079851; dbxref=FlyBase:FBpp0079448,FlyBase_Annotation_IDs:CG4379-PB,GB_protein:AAN10703.1,REFSEQ:NP_723479,GB_protein:AAN10703,UniProt/Swiss-Prot:P12370,FlyMine:FBpp0079448,modMine:FBpp0079448; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0089382; name=Pka-C1-PC; parent=FBgn0000273,FBtr0079852; dbxref=FlyBase:FBpp0089382,FlyBase_Annotation_IDs:CG4379-PC,GB_protein:AAS64669.1,REFSEQ:NP_995672,GB_protein:AAS64669,UniProt/Swiss-Prot:P12370; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(9696505..9697566); ID=FBpp0307466; name=Pka-C1-PD; parent=FBgn0000273,FBtr0335495; dbxref=REFSEQ:NP_476977,GB_protein:AAF52797,FlyBase:FBpp0307466,FlyBase_Annotation_IDs:CG4379-PD,UniProt/Swiss-Prot:P12370; MD5=dc5e07cc21ab1161a2358b88666e7cf0; length=353; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	353 amino acids
Gene Ontology:
Cellular Component:	cAMP-dependent protein kinase complex [ISS] plasma membrane [IDA]
Biological Process:	imaginal disc-derived leg morphogenesis [NAS] imaginal disc-derived wing morphogenesis [IMP] oocyte microtubule cytoskeleton polarization [IMP] olfactory learning [NAS] behavioral response to ethanol [NAS][TAS] protein amino acid phosphorylation [IEA][ISS][NAS] learning [NAS] anterior/posterior pattern formation, imaginal disc [IMP] negative regulation of smoothened signaling pathway [IGI] positive regulation of hh target transcription factor activity [IMP] compound eye development [NAS] memory [NAS] regulation of bicoid mRNA localization [IMP] oocyte anterior/posterior axis specification [IMP] rhythmic behavior [IMP][TAS] learning or memory [IMP][NAS] regulation of pole plasm oskar mRNA localization [IMP] anesthesia-resistant memory [IMP] oogenesis [IMP][TAS] locomotor rhythm [NAS] regulation of circadian sleep/wake cycle, sleep [IMP] cAMP-mediated signaling [NAS][TAS]
Molecular Function:	ATP binding [IEA] protein binding [IPI] cAMP-dependent protein kinase activity [ISS][NAS] protein serine/threonine kinase activity [IEA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNNATTSNK KVDAAETVKE FLEQAKEEFE DKWRRNPTNT AALDDFERIK TLGTGSFGRV  60
   61 MIVQHKPTKD YYAMKILDKQ KVVKLKQVEH TLNEKRILQA IQFPFLVSLR YHFKDNSNLY 120
  121 MVLEYVPGGE MFSHLRKVGR FSEPHSRFYA AQIVLAFEYL HYLDLIYRDL KPENLLIDSQ 180
  181 GYLKVTDFGF AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL VYEMAAGYPP 240
  241 FFADQPIQIY EKIVSGKVRF PSHFGSDLKD LLRNLLQVDL TKRYGNLKAG VNDIKNQKWF 300
  301 ASTDWIAIFQ KKIEAPFIPR CKGPGDTSNF DDYEEEALRI SSTEKCAKEF AEF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: FBpp0307466, Pka...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: