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Protein Overview: MEN1_RAT

General Information:
Name(s) found: MEN1_RAT [Swiss-Prot]
Description(s) found:
Found 21 descriptions.
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  • Menin OS=Rattus norvegicus GN=Men1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 610 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA][IEA]
    soluble fraction [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    cleavage furrow [UNKNOWN][IEA]
    histone methyltransferase complex [UNKNOWN][IEA]
    cytosol [UNKNOWN][IEA]
    nuclear matrix [UNKNOWN][IEA]
    protein complex [UNKNOWN][IEA]
    chromatin [UNKNOWN][IEA]
    Biological Process: cell cycle arrest [UNKNOWN][IEA]
    embryonic development [UNKNOWN][IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    hemopoiesis [UNKNOWN][IEA]
    positive regulation of histone methylation [UNKNOWN][IEA]
    palate development [UNKNOWN][IEA]
    negative regulation of cell cycle [UNKNOWN]
    positive regulation of transcription [UNKNOWN][IEA]
    response to UV [UNKNOWN][IEA]
    positive regulation of osteoblast differentiation [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    negative regulation of osteoblast differentiation [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    MAPKKK cascade [UNKNOWN][IEA]
    regulation of activin receptor signaling pathway [IMP]
    chromatin remodeling [UNKNOWN][IEA]
    positive regulation of cell division [UNKNOWN][IEA]
    ossification [UNKNOWN][IEA]
    histone methylation [UNKNOWN]
    response to gamma radiation [UNKNOWN][IEA]
    maternal process involved in female pregnancy [UNKNOWN][IEA]
    osteoblast fate commitment [UNKNOWN][IEA]
    negative regulation of transcription factor activity [UNKNOWN][IEA]
    positive regulation of cell differentiation [UNKNOWN]
    osteoblast development [UNKNOWN][IEA]
    brain development [IEP]
    negative regulation of organ growth [UNKNOWN][IEA]
    response to DNA damage stimulus [UNKNOWN][IEA]
    negative regulation of JNK cascade [UNKNOWN][IEA]
    negative regulation of cyclin-dependent protein kinase activity [UNKNOWN][IEA]
    embryonic skeletal system morphogenesis [UNKNOWN][IEA]
    positive regulation of caspase activity [UNKNOWN][IEA]
    leukocyte homeostasis [UNKNOWN][IEA]
    negative regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    negative regulation of transcription [UNKNOWN][IEA]
    positive regulation of apoptosis [UNKNOWN][IEA]
    negative regulation of telomerase activity [UNKNOWN][IEA]
    positive regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    transcription regulator activity [UNKNOWN][IEA]
    protein N-terminus binding [UNKNOWN][IEA]
    double-stranded DNA binding [UNKNOWN][IEA]
    histone-lysine N-methyltransferase activity [UNKNOWN][IEA]
    R-SMAD binding [UNKNOWN][IEA]
    Y-form DNA binding [UNKNOWN][IEA]
    chromatin binding [UNKNOWN][IEA]
    four-way junction DNA binding [UNKNOWN][IEA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE  60
   61 LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 120
  121 VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED 180
  181 HAWVVFGSNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV 240
  241 CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT 300
  301 LYHKGIASAK TYYQDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI 360
  361 YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQAQGTQGQ GSALQDPECF AHLLRFYDGI 420
  421 CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVHIVSR EAEAAEAEEP WGDEAREGRR 480
  481 RGPRRESKPE EPPPPKKPAL DKGPGSGQSA GSGPPRKTSG TVSGTARGTE VSSAAQAPAP 540
  541 AASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL 600
  601 SFLKRQRKGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle