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Protein Overview: HOP_RAT

General Information:
Name(s) found: HOP_RAT [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Homeodomain-only protein OS=Rattus norvegicus GN=Hopx PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 73 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    heart development [UNKNOWN][IEA]
    lung alveolus development [UNKNOWN][IEA]
    multicellular organismal development [IEA]
    negative regulation of cell differentiation [UNKNOWN]
    positive regulation of striated muscle cell differentiation [UNKNOWN][IEA]
    regulation of heart contraction [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IEA]
    trophectodermal cell differentiation [UNKNOWN][IEA]
    histone deacetylation [UNKNOWN][IEA]
    positive regulation of skeletal muscle tissue regeneration [UNKNOWN][IEA]
    Molecular Function: transcription factor activity [IEA]
    protein binding [UNKNOWN][IEA]
    sequence-specific DNA binding [IEA]
    transcription repressor activity [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAQTASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLTEEQTQKW FKQRLAEWRR  60
   61 SEGLPSECRS VTD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] PSI-BLAST 12.69897 No description for 2hi3A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • protein deacetylase activity
    		•  2.37116027682192 bayes_pls_golite062009
  • histone deacetylase activity
    		•  2.26220806496254 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • deacetylase activity
    		•  1.71115012708191 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  0.245458238105683 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.199316157622359 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.199316157622359 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.141400887946529 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.123848157052293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle