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Protein Overview: METTL3

General Information:
Name(s) found: METTL3 [HGNC (HUGO)]
Description(s) found:
Found 31 descriptions.
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  • methyltransferase like 3 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 580 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG  60
   61 PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL 120
  121 QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA GTVTGQKRRA 180
  181 EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK 240
  241 KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR 300
  301 RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS QELALTQSVG 360
  361 GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP 420
  421 VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK 480
  481 EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV 540
  541 QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] MSA 1.015953 View MSA. No confident structure predictions are available.
    2 View Details [142..231] deduced N/A No confident structure predictions are available.
    3 View Details [232..363] MSA 1.060992 View MSA. No confident structure predictions are available.
    4 View Details [364..580] FFAS03 1.04 Methyltransferase mboII

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • methyltransferase activity
    		•  3.68431317301075 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.64494850793256 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.60853685152199 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.51986359093355 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  3.47923436720314 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.91374296950366 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.666651371662 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  2.63941856307703 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • transferase activity
    		•  1.97261773840408 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  1.85380504590369 bayes_pls_golite062009
  • binding
    		•  1.65046086869658 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  1.64765900536818 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.59599828300594 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  1.5743030926483 bayes_pls_golite062009
  • DNA binding
    		•  1.48691268044769 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.38914410921124 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36595590938226 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.27753381141602 bayes_pls_golite062009
  • DNA (cytosine-5-)-methyltransferase activity
    		•  1.23915163423518 bayes_pls_golite062009
  • catalytic activity
    		•  1.16970557486814 bayes_pls_golite062009
  • RNA binding
    		•  1.10288658549985 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.862671287243863 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.837734735695963 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  0.735680462496249 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.51222176401398 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  0.325961687103877 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  0.325961687103877 bayes_pls_golite062009
  • histone binding
    		•  0.230289474831554 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.113328595762489 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.0390774859535424 bayes_pls_golite062009
  • mRNA methyltransferase activity
    		•  0.03091406523028 bayes_pls_golite062009
  • mRNA (guanine-N7-)-methyltransferase activity
    		•  0.03091406523028 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle