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Protein Overview: PRDX2

General Information:
Name(s) found: PRDX2 [HGNC (HUGO)]
Description(s) found:
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  • gi|77744389|gb|ABB02182.1| peroxiredoxin 2 [Homo sapiens] [NCBI NR]
  • gi|49456535|emb|CAG46588.1| PRDX2 [Homo sapiens] [NCBI NR]
  • gi|47496659|emb|CAG29352.1| PRDX2 [Homo sapiens] [NCBI NR]
  • gi|32189392|ref|NP_005800.3| peroxiredoxin 2 isoform a [Homo sapiens] [NCBI NR]
  • gi|2507169|sp|P32119.5|PRDX2_HUMAN RecName: Full=Peroxiredoxin-2; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=PRP; AltName: Fu [NCBI NR]
  • gi|24659879|gb|AAH39428.1| Peroxiredoxin 2 [Homo sapiens] [NCBI NR]
  • gi|12804327|gb|AAH03022.1| Peroxiredoxin 2 [Homo sapiens] [NCBI NR]
  • gi|12653365|gb|AAH00452.1| Peroxiredoxin 2 [Homo sapiens] [NCBI NR]
  • gi|119604715|gb|EAW84309.1| peroxiredoxin 2, isoform CRA_b [Homo sapiens] [NCBI NR]
  • peroxiredoxin 2 [HGNC (HUGO)]
  • Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 [Swiss-Prot]
  • (P32119) Peroxiredoxin 2 (EC 1.11.1.-) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thiol-specific antioxidant protein) (TSA) (PRP) (Natural killer cell enhancing factor B) (NKEF-B) [Swiss-Prot]
  • Peroxiredoxin 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • peroxiredoxin 2 isoform a; thioredoxin-dependent peroxide reductase 1; thiol-specific antioxidant 1; natural killer-enhancing factor B; thioredoxin peroxidase 1; torin [HMR_022704.fasta]
  • peroxiredoxin 2 isoform a [Homo sapiens]gi|24659879|gb|AAH39428.1| Peroxiredoxin 2, isoform a [Homo sapiens]gi|12653365|gb|AAH00452.1| Peroxiredoxin 2, isoform a [Homo sapiens]gi|12804327|gb|AAH03022.1| Peroxiredoxin 2, isoform a [Homo sapiens]gi|4945 [nrdb_11152004_Chlamydomonas]
  • Peroxiredoxin 2 (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thiol-specific antioxidant protein) (TSA) (PRP) (Natural killer cell enhancing factor B) (NKEF-B) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • peroxiredoxin 2 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Peroxiredoxin 2 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • peroxiredoxin 2 isoform a; thioredoxin-dependent peroxide reductase 1; thiol-specific antioxidant 1; natural killer-enhancing factor B; thioredoxin peroxidase 1; torin [Homo sapiens] [HumanGallus06162005.fasta]
  • Peroxiredoxin-2 (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thiol-specific antioxidant protein) (TSA) (PRP) (Natural killer cell-enhancing factor B) (NKEF-B) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • peroxiredoxin 2, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Peroxiredoxin 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • peroxiredoxin 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • PRDX2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PEROXIREDOXIN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PRDX2 Peroxiredoxin-2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00027350.3|SWISS-PROT:P32119|ENSEMBL:ENSP00000301522|REFSEQ:NP_005800|H-INV:HIT000277909|VEGA:OTTHUMP00000077857;OTTHUMP00000165823 Tax_Id=9606 Gene_Symbol=PRDX2 Peroxiredoxin-2 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Peroxiredoxin-2 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PRDX2 Peroxiredoxin-2 ENSG00000167815 IPI00375400 IPI00027350 IPI00375401 IPI00794777 [drosphohumanreversed.fasta]
  • peroxiredoxin-2 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P32119;P31945;P32118;P35701;Q6FHG4;Q92763;Q9UC23; RecName: Full=Peroxiredoxin-2; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1; AltName: Full=Thiol-specific antioxidant protein; AltName: Full=PRP; AltName: Full=Natural killer cell-enhancing factor B; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 [011711_HMR.fasta]
  • GeneSymbol=PRDX2 Synonyms=MGC4104|NKEFB|PRP|PRX2|PRXII|TDPX1|TPX1|TSA peroxiredoxin-2 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00027350.3|SWISS-PROT:P32119|ENSEMBL:ENSP00000301522|REFSEQ:NP_005800|H-INV:HIT000277909|VEGA:OTTHUMP00000165823 Tax_Id=9606 Gene_Symbol=PRDX2 Peroxiredoxin-2 [ipi.HUMAN.20110912.fasta]
  • Peroxiredoxin-2 GN=PRDX2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Epididymis secretory sperm binding protein Li 2a OS=Homo sapiens GN=HEL-S-2a PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 198 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN  60
   61 RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT 120
  121 DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS 180
  181 DTIKPNVDDS KEYFSKHN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] PSI-BLAST 69.522879 Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alkyl hydroperoxide reductase activity
    		•  4.29610283853788 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • selenium binding
    		•  2.92496040718744 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transferase activity
    		•  1.26687471229876 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptide binding
    		•  0.374493676068876 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle