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Protein Overview: LEMD3

General Information:
Name(s) found: LEMD3 [HGNC (HUGO)]
Description(s) found:
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  • gi|7706607|ref|NP_055134.2| LEM domain containing 3 [Homo sapiens] [NCBI NR]
  • gi|7657560|gb|AAD31593.2|AF112299_1 integral inner nuclear membrane protein MAN1 [Homo sapiens] [NCBI NR]
  • gi|13629600|sp|Q9Y2U8.2|MAN1_HUMAN RecName: Full=Inner nuclear membrane protein Man1; AltName: Full=LEM domain-containing protein 3 [NCBI NR]
  • gi|119617555|gb|EAW97149.1| LEM domain containing 3, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119617554|gb|EAW97148.1| LEM domain containing 3, isoform CRA_a [Homo sapiens] [NCBI NR]
  • LEM domain containing 3 [HGNC (HUGO)]
  • Inner nuclear membrane protein Man1 OS=Homo sapiens GN=LEMD3 PE=1 SV=2 [Swiss-Prot]
  • Inner nuclear membrane protein Man1 [hmr_yeast5_DM3-1_pombe.fasta]
  • integral inner nuclear membrane protein [HMR_022704.fasta]
  • integral inner nuclear membrane protein [Homo sapiens]gi|7657560|gb|AAD31593.2| integral inner nuclear membrane protein MAN1 [Homo sapiens]gi|13629600|sp|Q9Y2U8|MAN1_HUMAN Inner nuclear membrane protein Man1 [nrdb_11152004_Chlamydomonas]
  • Inner nuclear membrane protein Man1 (LEM domain containing protein 3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Inner nuclear membrane protein Man1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_014319) integral inner nuclear membrane protein [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • LEM domain containing 3 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • integral inner nuclear membrane protein [Homo sapiens] [HumanGallus06162005.fasta]
  • Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • LEM domain containing 3, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • integral inner nuclear membrane protein MAN1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 INNER NUCLEAR MEMBRANE PROTEIN MAN1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LEMD3 Inner nuclear membrane protein Man1 [human-ipi-250309-contam.fasta]
  • LEM domain containing 3 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_02-15-2010_reversed.fasta]
  • IPI:IPI00032491.1|SWISS-PROT:Q9Y2U8|TREMBL:B4DI45;B4E2K7|ENSEMBL:ENSP00000308369|REFSEQ:NP_055134|H-INV:HIT000069729|VEGA:OTTHUMP00000168362 Tax_Id=9606 Gene_Symbol=LEMD3 Inner nuclear membrane protein Man1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=LEMD3 Inner nuclear membrane protein Man1 ENSG00000174106 IPI00032491 [drosphohumanreversed.fasta]
  • inner nuclear membrane protein Man1 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9Y2U8;Q9NT47;Q9NYA5; RecName: Full=Inner nuclear membrane protein Man1; AltName: Full=LEM domain-containing protein 3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Inner nuclear membrane protein Man1 OS=Homo sapiens GN=LEMD3 [011711_HMR.fasta]
  • IPI:IPI00032491.1|SWISS-PROT:Q9Y2U8|ENSEMBL:ENSP00000308369|REFSEQ:NP_055134|H-INV:HIT000069729|VEGA:OTTHUMP00000168362 Tax_Id=9606 Gene_Symbol=LEMD3 Inner nuclear membrane protein Man1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=LEMD3 Synonyms=MAN1 inner nuclear membrane protein Man1 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00032491.1|SWISS-PROT:Q9Y2U8|ENSEMBL:ENSP00000308369|REFSEQ:NP_055134|H-INV:HIT000069729|VEGA:OTTHUMP00000239603 Tax_Id=9606 Gene_Symbol=LEMD3 Inner nuclear membrane protein Man1 [ipi.HUMAN.20110912.fasta]
  • Inner nuclear membrane protein Man1 GN=LEMD3 [Doctor+uniprot-HUMAN-120911.fasta]
  • LEM domain containing 3, isoform CRA_a OS=Homo sapiens GN=LEMD3 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 911 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAASAPQ QLSDEELFSQ LRRYGLSPGP VTESTRPVYL KKLKKLREEE QQQHRSGGRG  60
   61 NKTRNSNNNN TAAATVAAAG PAAAAAAGMG VRPVSGDLSY LRTPGGLCRI SASGPESLLG 120
  121 GPGGASAAPA AGSKVLLGFS SDESDVEASP RDQAGGGGRK DRASLQYRGL KAPPAPLAAS 180
  181 EVTNSNSAER RKPHSWWGAR RPAGPELQTP PGKDGAVEDE EGEGEDGEER DPETEEPLWA 240
  241 SRTVNGSRLV PYSCRENYSD SEEEDDDDVA SSRQVLKDDS LSRHRPRRTH SKPLPPLTAK 300
  301 SAGGRLETSV QGGGGLAMND RAAAAGSLDR SRNLEEAAAA EQGGGCDQVD SSPVPRYRVN 360
  361 AKKLTPLLPP PLTDMDSTLD SSTGSLLKTN NHIGGGAFSV DSPRIYSNSL PPSAAVAASS 420
  421 SLRINHANHT GSNHTYLKNT YNKPKLSEPE EELLQQFKRE EVSPTGSFSA HYLSMFLLTA 480
  481 ACLFFLILGL TYLGMRGTGV SEDGELSIEN PFGETFGKIQ ESEKTLMMNT LYKLHDRLAQ 540
  541 LAGDHECGSS SQRTLSVQEA AAYLKDLGPE YEGIFNTSLQ WILENGKDVG IRCVGFGPEE 600
  601 ELTNITDVQF LQSTRPLMSF WCRFRRAFVT VTHRLLLLCL GVVMVCVVLR YMKYRWTKEE 660
  661 EETRQMYDMV VKIIDVLRSH NEACQENKDL QPYMPIPHVR DSLIQPHDRK KMKKVWDRAV 720
  721 DFLAANESRV RTETRRIGGA DFLVWRWIQP SASCDKILVI PSKVWQGQAF HLDRRNSPPN 780
  781 SLTPCLKIRN MFDPVMEIGD QWHLAIQEAI LEKCSDNDGI VHIAVDKNSR EGCVYVKCLS 840
  841 PEYAGKAFKA LHGSWFDGKL VTVKYLRLDR YHHRFPQALT SNTPLKPSNK HMNSMSHLRL 900
  901 RTGLTNSQGS S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] PSI-BLAST 17.0 No description for 1y0fB was found.
    2 View Details [431..642] deduced N/A No confident structure predictions are available.
    3 View Details [643..771] PSI-BLAST 30.0 No description for 2ch0A was found.
    4 View Details [772..911] PSI-BLAST 16.0 Hu antigen C (Huc)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.29041217255208 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91189490017911 bayes_pls_golite062009
  • RNA binding
    		•  1.38087228196877 bayes_pls_golite062009
  • mRNA binding
    		•  0.27767437285052 bayes_pls_golite062009
  • protein binding
    		•  0.0101134374085809 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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