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Protein Overview: FXN

General Information:
Name(s) found: FXN [HGNC (HUGO)]
Description(s) found:
Found 32 descriptions.
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  • frataxin [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 210 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC TPRRASSNQR  60
   61 GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF 120
  121 EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV 180
  181 SLHELLAAEL TKALKTKLDL SSLAYSGKDA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] MSA 2.031971 View MSA. No confident structure predictions are available.
    2 View Details [90..210] PSI-BLAST 48.69897 C-terminal domain of frataxin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • iron chaperone activity
    		•  4.16905358201916 bayes_pls_golite062009
  • ferric iron binding
    		•  3.23865994858009 bayes_pls_golite062009
  • iron ion binding
    		•  2.78584553912929 bayes_pls_golite062009
  • 2 iron, 2 sulfur cluster binding
    		•  2.25545886640675 bayes_pls_golite062009
  • transition metal ion binding
    		•  1.85229574432416 bayes_pls_golite062009
  • binding
    		•  1.75179885686234 bayes_pls_golite062009
  • metallochaperone activity
    		•  1.67572555512957 bayes_pls_golite062009
  • ferrous iron binding
    		•  1.61332056179381 bayes_pls_golite062009
  • protein binding
    		•  1.50639308293007 bayes_pls_golite062009
  • cation binding
    		•  1.42164579673909 bayes_pls_golite062009
  • metal ion binding
    		•  1.42164579673909 bayes_pls_golite062009
  • ion binding
    		•  1.4150396069236 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.07282105096776 bayes_pls_golite062009
  • metal cluster binding
    		•  0.602901470550009 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  0.602901470550009 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
    		•  0.310374472796773 bayes_pls_golite062009
  • ferroxidase activity
    		•  0.310374472796773 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle