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Protein Overview: SMY2

General Information:
Name(s) found: SMY2 / YBR172C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 740 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAPDSQRLF GSFDEQFKDL KLDSVDTENN NTHGVSTILD SSPASVNNNT NGAVAASVNT  60
   61 VPGSTFRSNT PLLGGRHPLS RTSSLIDSIG IQRAASPFSS MKEPFIPQSS GVMSSSFWHG 120
  121 DHPESRVSTP VQQHPLLQRN ESSSSFSYAA NLGVNLSTHS LAVDITPLST PTAAQSHVNL 180
  181 FPSSDIPPNM SMNGMSQLPA PVSVESSWRY IDTQGQIHGP FTTQMMSQWY IGGYFASTLQ 240
  241 ISRLGSTPET LGINDIFITL GELMTKLEKY DTDPFTTFDK LHVQTTSSDS INLNLAPYAS 300
  301 GVAATGTIKA TENDIFKPLT HDNIWDMDGG TTSKGVDIKL ASATTISQTD ESHKQEYKST 360
  361 TMLEKGKKEK SESVAKALLD EQEKRNRELK RKEEARLSKK QKQKEDDLLK KQKEQKEQKE 420
  421 KEALEAEKQK KSEKTKKDTQ TQTEGFKTSK DLPSLNSSSA NPAPWASKVK VNNAIETSIK 480
  481 NGVSSTGKKK GEPLGLQQRN SKEEKQKEEL KSVLNWANKS SLPSNQTIDI KSQFQKSPKG 540
  541 MKESSPLKEL EDPNFIEEQK KLWEKVQSSS KQVKSTSSAS TTTSSWTTVT SKGKAPIGTV 600
  601 VSPYSKTNTS LNSSLTAKTS TTSTTTTFAS MNNVSPRQEF IKWCKSQMKL NSGITNNNVL 660
  661 ELLLSLPTGP ESKELIQETI YANSDVMDGR RFATEFIKRR VACEKQGDDP LSWNEALALS 720
  721 GNDDDGWEFQ VVSKKKGRKH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) MYO1 MYO2 MYO3 MYO4 MYO5 SMY1 SMY2
    View Details Qiu et al. (2008) MYO2 SMY2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SMY2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] MSA 4.154995 View MSA. No confident structure predictions are available.
    2 View Details [179..634] PSI-BLAST 19.154902 Heavy meromyosin subfragment
    3 View Details [635..740] PSI-BLAST 4.221849 Tropomyosin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle