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Protein Overview: IRC21

General Information:
Name(s) found: IRC21 / YMR073C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDGMNRDV SNSKPNVRFA APQRLSVAHP AISSPLHMPM SKSSRKPLVR TKIRLDPGHS  60
   61 ALDWHSLTSN PANYYTKFVS LQLIQDLLDD PVFQKDNFKF SPSQLKNQLL VQKIPLYKIM 120
  121 PPLRINRKIV KKHCKGEDEL WCVINGKVYD ISSYLKFHPG GTDILIKHRN SDDLITYFNK 180
  181 YHQWVNYEKL LQVCFIGVVC E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IRC21 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..201] PSI-BLAST 71.512579 Cytochrome b5


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle