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Protein Overview: DUS1

General Information:
Name(s) found: DUS1 / YML080W [SGD]
Description(s) found:
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  • gi|6323560|ref|NP_013631.1| Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; Dus1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|630106|pir||S48817 hypothetical protein YML080w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|587531|emb|CAA86498.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1730621|sp|P53759.1|DUS1_YEAST RecName: Full=tRNA-dihydrouridine synthase 1 [NCBI NR]
  • tRNA-dihydrouridine synthase 1 OS=Saccharomyces cerevisiae GN=DUS1 PE=1 SV=1 [Swiss-Prot]
  • DUS1 Member of dihydrouridine synthase family [mips]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 [SGD]
  • DUS1, Chr XIII from 108806-110077 [yeast_orfs2]
  • Chr XIII from 108806-110077 [yeastorf3.fasta]
  • (P53759) tRNA-dihydrouridine synthase 1 (EC 1.-.-.-) [4932.FASTACCERV.txt]
  • DUS1 SGDID:S0004545, Chr XIII from 108806-110077, Verified ORF [yeastflysequest.fasta]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 [Saccharomyces cerevisiae]gi|587531|emb|CAA86498.1| unnamed protein product [Saccharomyces cerevisiae]gi|173062 [nrdb_11152004_Chlamydomonas]
  • DUS1 SGDID:S000004545, Chr XIII from 108806-110077, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • tRNA-dihydrouridine synthase 1 [nr-271106-contam.fasta]
  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; Dus1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DUS1 SGDID:S000004545, Chr XIII from 108806-110077, Genome Release 64-1-1, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17" [yeast-030211-contam.fasta]
  • DUS1 SGDID:S000004545, Chr XIII from 108806-110077, Genome Release 64-2-1, Verified ORF, "Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17" [20141208_orf_trans.fasta]
  • YML080W SGDID:S000004545, Chr XIII from 108806-110077, Genome Release 64-1-1, Verified ORF, "Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: tRNA modification [IDALink to PubMed article]
    Molecular Function: tRNA dihydrouridine synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEPALSSAN NALMQKLTGR QLFDKIGRPT RIVAPMVDQS ELAWRILSRR YGATLAYTPM  60
   61 LHAKLFATSK KYREDNWSSL DGSSVDRPLV VQFCANDPEY LLAAAKLVED KCDAVDLNLG 120
  121 CPQGIAKKGH YGSFLMEEWD LIHNLINTLH KNLKVPVTAK IRIFDDCEKS LNYAKMVLDA 180
  181 GAQFLTVHGR VREQKGQKTG LANWETIKYL RDNLPKETVF FANGNILYPE DISRCMEHIG 240
  241 ADAVMSAEGN LYNPGVFNVG QTKNKEKIFP RVDKIIREYF QIVKECQESK ASKTAMKSHF 300
  301 FKILRPFLPH HTDIRSTLAT MNAKATWEEW EEQVVKPVEK VVQEIFEQPD IAIKDEITIG 360
  361 EKQSWGGSYR TVPYWRCQPY FRPVNGITGD KRVMQGLIDE SVNKKRKADV PLESADKKKD 420
  421 VKA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) DUS1 DUS3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DUS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 35.154902 Glycolate oxidase
    2 View Details [366..423] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • tRNA dihydrouridine synthase activity
    		•  1.94490879164338 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03692680161964 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.876786102965635 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.80115790656025 bayes_pls_golite062009
  • binding
    		•  0.68572942532795 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle