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Protein Overview: MET1

General Information:
Name(s) found: MET1 / YKR069W [SGD]
Description(s) found:
Found 23 descriptions.
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  • S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 593 amino acids

    Gene Ontology:
    Cellular Component: intracellular [ICLink to PubMed articleLink to PubMed article]
    Biological Process: methionine biosynthetic process [IMPLink to PubMed article]
    siroheme biosynthetic process [IGILink to PubMed article][ISSLink to PubMed article]
    sulfate assimilation [NASLink to PubMed article]
    Molecular Function: uroporphyrin-III C-methyltransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG GNPIVVNPSS  60
   61 PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV VDRVFVDLPI TQSRLCEEIF 120
  121 WQCQKLRIPI NTFHKPEFST FNMIPTWVDP KGSGLQISVT TNGNGYILAN RIKRDIISHL 180
  181 PPNISEVVIN MGYLKDRIIN EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR 240
  241 EFEMTSREQR LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT 300
  301 DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK SADIILADKL 360
  361 VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL DNGLKVVRLK QGDPYIFGRG 420
  421 GEEFNFFKDH GYIPVVLPGI SSSLACTVLA QIPATQRDIA DQVLICTGTG RKGALPIIPE 480
  481 FVESRTTVFL MALHRANVLI TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE 540
  541 EIGSRPPGVL VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 34.522879 Bifunctional dehydrogenase/ferrochelatase Met8p, N-terminal domain; Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
    2 View Details [217..321] deduced N/A No confident structure predictions are available.
    3 View Details [322..441] PSI-BLAST 213.70927 Cobalt precorrin-4 methyltransferase CbiF
    4 View Details [442..593] PSI-BLAST 213.70927 Cobalt precorrin-4 methyltransferase CbiF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uroporphyrin-III C-methyltransferase activity
    		•  3.573271502205 bayes_pls_golite062009
  • C-methyltransferase activity
    		•  3.35393353163232 bayes_pls_golite062009
  • precorrin-4 C11-methyltransferase activity
    		•  2.18371138649366 bayes_pls_golite062009
  • catalytic activity
    		•  1.48349578618275 bayes_pls_golite062009
  • transferase activity
    		•  0.912524944496351 bayes_pls_golite062009
  • binding
    		•  0.591538530271277 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.463693177369635 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.454156823400351 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.323461631906645 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • protein binding
    		•  0.0615599502226839 bayes_pls_golite062009
  • uroporphyrinogen-III synthase activity
    		•  0.00871858903098705 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle