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Protein Overview: CDC20

General Information:
Name(s) found: CDC20 / YGL116W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 610 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    activation of mitotic anaphase-promoting complex activity [IMPLink to PubMed articleLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    Molecular Function: enzyme activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPESSRDKGN AAISGNRSVL SIASPTKLNI LSSDWSRNQG KVSKNSLKRS SSLNIRNSKR  60
   61 PSLQASANSI YSRPKITIGA PPLIRRDSSF FKDEFDAKKD KATFSAYSSR SYPTIGSESV 120
  121 VSQTSLSQPT TSREVDEQFT VAADRYIPIL QGASQNKVDP ETLHEALPPP NASPISHLRA 180
  181 QTKIVFKQNV AEACGLDMNK RILQYMPEPP KCSSLRQKSY IMKKRTHYSY QQEQKIPDLI 240
  241 KLRKINTNPE RILDAPGFQD DFYLNLLSWS KKNVLAIALD TALYLWNATT GDVSLLTDFE 300
  301 NTTICSVTWS DDDCHISIGK EDGNTEIWDV ETMSLIRTMR SGLGVRIGSL SWLDTLIATG 360
  361 SRSGEIQIND VRIKQHIVST WAEHTGEVCG LSYKSDGLQL ASGGNDNTVM IWDTRTSLPQ 420
  421 FSKKTHTAAV KALSWCPYSP NILASGGGQT DKHIHFWNSI TGARVGSINT GSQVSSLHWG 480
  481 QSHTSTNGGM MNKEIVATGG NPENAISVYN YETKFKVAEV VHAHEARICC SQLSPDGTTL 540
  541 ATVGGDENLK FYKIFDPRCT GRSREDGLMD GMLGLIGKEG CRTNDKENRS KNSSEIHTRR 600
  601 PSSTSQYLIR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT5 CDC20 MAD3 MDH1 MKK2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] PSI-BLAST 7.154902 TolB, C-terminal domain; TolB, N-terminal domain
    2 View Details [178..437] PSI-BLAST 7.154902 TolB, C-terminal domain; TolB, N-terminal domain
    3 View Details [438..610] PSI-BLAST 123.512579 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.24355753923746 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle