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Protein Overview: GCN4

General Information:
Name(s) found: GCN4 / YEL009C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: positive regulation of gene-specific transcription involved in unfolded protein response [IMPLink to PubMed article]
    cellular amino acid biosynthetic process [TASLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEYQPSLFA LNPMGFSPLD GSKSTNENVS ASTSTAKPMV GQLIFDKFIK TEEDPIIKQD  60
   61 TPSNLDFDFA LPQTATAPDA KTVLPIPELD DAVVESFFSS STDSTPMFEY ENLEDNSKEW 120
  121 TSLFDNDIPV TTDDVSLADK AIESTEEVSL VPSNLEVSTT SFLPTPVLED AKLTQTRKVK 180
  181 KPNSVVKKSH HVGKDDESRL DHLGVVAYNR KQRSIPLSPI VPESSDPAAL KRARNTEAAR 240
  241 RSRARKLQRM KQLEDKVEEL LSKNYHLENE VARLKKLVGE R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GCN4 REH1 RPL41A, RPL41B RPS29A

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 GCN4 2 Unpublished Fields Lab Data
    View Screen MPC54 GCN4 2 Unpublished Fields Lab Data
    View Screen UMP1 GCN4 1 Unpublished Fields Lab Data
    View Screen STE50 GCN4 1 Unpublished Fields Lab Data
    View Screen CDC34 GCN4 1 Unpublished Fields Lab Data
    View Screen CKB1 GCN4 1 Unpublished Fields Lab Data
    View Screen ROM1 GCN4 1 Unpublished Fields Lab Data
    View Screen YHR022C GCN4 1 Unpublished Fields Lab Data
    View Screen PAM18 GCN4 1 Unpublished Fields Lab Data
    View Screen TOP3 GCN4 1 Unpublished Fields Lab Data
    View Screen SUI1 GCN4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GCN4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] MSA 10.324997 View MSA. No confident structure predictions are available.
    2 View Details [200..281] PSI-BLAST 256.9794 GCN4
    3 View Details [220..281] PSI-BLAST 14.30103 GCN4


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle