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Protein Overview: MSH5

General Information:
Name(s) found: MSH5 / YDL154W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 901 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: reciprocal meiotic recombination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHEWLISAS ETMRSIGNGE GLRDKGAVVA NNDGEFNEGD TNREEDSSTI FSFDFDEEIV  60
   61 MCIDFSGGKL GCSILDYHTK TLKAFDQDYV VNKTTISSHD LIDDADMSSN DISLLLGLLI 120
  121 MEANPTVCLV PARLEDWIFD YIKTKCDEIN CRLELQPIKR FKKWDLLQSL QLRGHDNQTI 180
  181 LNDILSNSKF TTTVTLGTVG CILANHEQLG EYNDSTASSN MVTGRLVQNA FEDVIHGIRY 240
  241 IDIRDRMVLD ENTISALHIF PTAHKLGHDK MMRNGFFSVF ELFNQVSSDY ARRILKSWLI 300
  301 NPLTNKKRIE TRYSIIRTLL DKQNAIIFSD LSQSIKRCPD AFGFINQLRS GKSTLGTWSK 360
  361 VASFLEKGIA IFQLVSSLKL GSDEANILHD IKNKVDISAL KECLRKVETV IDFDTSRDTK 420
  421 TLTINTGVDN RLDECRNIYN HLEGILLDVA RETQIFLLNT MPQEDCKTTK SLEKLVNAVY 480
  481 IPQLGYLVTI SVLMEPLLDG IPNLQWEEIF RSSENIYFKN GRVLELDETY GDIYGAISDF 540
  541 EIEILFSLQE QILRRKTQLT AYNILLSELE ILLSFAQVSA ERNYAEPQLV EDECILEIIN 600
  601 GRHALYETFL DNYIPNSTMI DGGLFSELSW CEQNKGRIIV VTGANASGKS VYLTQNGLIV 660
  661 YLAQIGCFVP AERARIGIAD KILTRIRTQE TVYKTQSSFL LDSQQMAKSL SLATEKSLIL 720
  721 IDEYGKGTDI LDGPSLFGSI MLNMSKSEKC PRIIACTHFH ELFNENVLTE NIKGIKHYCT 780
  781 DILISQKYNL LETAHVGEDH ESEGITFLFK VKEGISKQSF GIYCAKVCGL SRDIVERAEE 840
  841 LSRMINRGDD VVQQCGNLTE KEMREFQKNQ EIVKKFLSWD LDLETTTTSE NLRLKLKNFL 900
  901 R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..244] PSI-BLAST 1265.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    2 View Details [245..273]
    [580..901]    		 PSI-BLAST 1265.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    3 View Details [274..439]
    [532..579]    		 PSI-BLAST 1265.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    4 View Details [440..531] PSI-BLAST 1265.228787 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle