Protein Overview: AK2H_ECOLI

General Information:
Name(s) found:	AK2H_ECOLI [Swiss-Prot]
Description(s) found: Found 8 descriptions. SHOW ALL	Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II (EC 2.7.2.4); Homoserine dehydrogenase II (EC 1.1.1.3)] - Escherichia coli [Swiss-Prot]
Organism:	Escherichia coli
Length:	810 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVIAQAGAK GRQLHKFGGS SLADVKCYLR VAGIMAEYSQ PDDMMVVSAA GSTTNQLINW  60
   61 LKLSQTDRLS AHQVQQTLRR YQCDLISGLL PAEEADSLIS AFVSDLERLA ALLDSGINDA 120
  121 VYAEVVGHGE VWSARLMSAV LNQQGLPAAW LDAREFLRAE RAAQPQVDEG LSYPLLQQLL 180
  181 VQHPGKRLVV TGFISRNNAG ETVLLGRNGS DYSATQIGAL AGVSRVTIWS DVAGVYSADP 240
  241 RKVKDACLLP LLRLDEASEL ARLAAPVLHA RTLQPVSGSE IDLQLRCSYT PDQGSTRIER 300
  301 VLASGTGARI VTSHDDVCLI EFQVPASQDF KLAHKEIDQI LKRAQVRPLA VGVHNDRQLL 360
  361 QFCYTSEVAD SALKILDEAG LPGELRLRQG LALVAMVGAG VTRNPLHCHR FWQQLKGQPV 420
  421 EFTWQSDDGI SLVAVLRTGP TESLIQGLHQ SVFRAEKRIG LVLFGKGNIG SRWLELFARE 480
  481 QSTLSARTGF EFVLAGVVDS RRSLLSYDGL DASRALAFFN DEAVEQDEES LFLWMRAHPY 540
  541 DDLVVLDVTA SQQLADQYLD FASHGFHVIS ANKLAGASDS NKYRQIHDAF EKTGRHWLYN 600
  601 ATVGAGLPIN HTVRDLIDSG DTILSISGIF SGTLSWLFLQ FDGSVPFTEL VDQAWQQGLT 660
  661 EPDPRDDLSG KDVMRKLVIL AREAGYNIEP DQVRVESLVP AHCEGGSIDH FFENGDELNE 720
  721 QMVQRLEAAR EMGLVLRYVA RFDANGKARV GVEAVREDHP LASLLPCDNV FAIESRWYRD 780
  781 NPLVIRGPGA GRDVTAGAIQ SDINRLAQLL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..454]	PSI-BLAST	90.221849	No description for 2hmfA was found.
2	View Details	[455..810]	PSI-BLAST	68.522879	Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
acetolactate synthase activity	6.25735158730374	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	5.28856942236052	bayes_pls_golite062009
aspartate kinase activity	3.23731032633773	bayes_pls_golite062009
kinase activity	3.13431949100327	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.94061415123563	bayes_pls_golite062009
catalytic activity	2.83338756483354	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	2.65970393362911	bayes_pls_golite062009
transcription regulator activity	2.54193538468834	bayes_pls_golite062009
amino acid kinase activity	2.38310367076654	bayes_pls_golite062009
transferase activity	2.34413838821786	bayes_pls_golite062009
nucleic acid binding	1.77420728550693	bayes_pls_golite062009
DNA binding	1.70654139251388	bayes_pls_golite062009
binding	1.61057316956254	bayes_pls_golite062009
acetylglutamate kinase activity	1.28891782911186	bayes_pls_golite062009
transcription factor activity	1.13755026342338	bayes_pls_golite062009
transcription repressor activity	0.61058430787131	bayes_pls_golite062009
glutamate 5-kinase activity	0.416864856459166	bayes_pls_golite062009
protein binding	0.178881469836152	bayes_pls_golite062009

2

Term	Confidence	Notes
aspartate-semialdehyde dehydrogenase activity	2.99580112154281	bayes_pls_golite062009
dihydrodipicolinate reductase activity	2.74085594134831	bayes_pls_golite062009
catalytic activity	2.54843319568228	bayes_pls_golite062009
transcription regulator activity	1.90939908578582	bayes_pls_golite062009
oxidoreductase activity	1.84451425136793	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
binding	1.22114607236074	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
phosphoglycerate dehydrogenase activity	0.639509916626856	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.610531769148819	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.610013758225609	bayes_pls_golite062009
saccharopine dehydrogenase activity	0.495113665163626	bayes_pls_golite062009
ketol-acid reductoisomerase activity	0.414784304540676	bayes_pls_golite062009
structural molecule activity	0.160242197882814	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	0.0651785123513661	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
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