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View Structure Prediction Details

Protein: rn-PE
Organism: Drosophila melanogaster
Length: 946 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rn-PE.

Description E-value Query
Range
Subject
Range
gi|114671709 - gi|114671709|ref|XP_511785.2| PREDICTED: zinc finger protein 624 [Pan troglodytes]
971.0 [0..116] [945..392]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIMHGTWYKG PQLAHHPHSN PHNSSHGHSD YHQFRSYPSF VVTPYHDGHV QGPATPTPCT  60
   61 APPTPCNGPV PVSVPVSIPV CHTGGQGSPV IVESSFAIAA AAAAAAAAVA VGGSSATPLL 120
  121 PSPPIKIEQV FGEPSSLGAV VEDYALGLDC PVEHTFRKPH NNNGYSWSTG NNNEVVSHSS 180
  181 NGHTNNHPTT PPTPPNEASA TQATSVSAIN LNQAQPASQT RSNFGSSIKS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [231-428]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPSEPDAVTA ATCKSQENNS GQNPTPNSLS DHNPAHNLNS NSTAAAVAAA AAAAAAANMP  60
   61 IGGVQGQNPT QGLVHWMSAV MAEHMTGQTH HDPGAVGMHY MWNGNVDHAK DISDYNLWPP 120
  121 TPRSHQHASE HHPMSLKQEY EAKMNDHHHN NLQKGHFLDD NRLEHHAVTG QGGLGLGASN 180
  181 GVGGGGGGAS VVGNSSLG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [429-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSHHAVAAA HHHNQAVAAA SAAALLVVPQ PINASKMGGP G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [470-658]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVSSVAGGHA TGGGSGRKYQ CKMCPQIFSS KADLQLHTQI HMREAKPYKC TQCSKAFANS  60
   61 SYLSQHTRIH LGIKPYRCEI CQRKFTQLSH LQQHIRTHTG DKPYKCRHPG CQKAFSQLSN 120
  121 LQSHSRCHQT DKPFKCNSCY KCFSDEPSLL EHIPKHKESK HLKTHICQYC GKSYTQETYL 180
  181 TKHMQKHAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.045757
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #5
Region A:
Residues: [659-752]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTDKRPPIVP GSAAAIAAAA AAAAGGSANP ANGPPPPPNP AQHQRNNLGL PPVSIAPSDN  60
   61 GYWPKVSPDS AAAANAMEVM HQQQQQQQQQ QQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [753-824]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQQQQQQ AHHHHPQHGV PPQQHVPPQQ QQQQQQQQQH HHPQQQPPPQ HSMEAHYAQP  60
   61 TAPNGSQSNG HG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.71642591026275 bayes_pls_golite062009
transcription regulator activity 3.66965352784412 bayes_pls_golite062009
DNA binding 3.60136746748155 bayes_pls_golite062009
transcription factor activity 2.54048357633122 bayes_pls_golite062009
binding 2.46754839887217 bayes_pls_golite062009
transcription repressor activity 2.40376744272574 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.29326096340736 bayes_pls_golite062009
chromatin binding 1.30140469366308 bayes_pls_golite062009
transcription activator activity 1.29100548621048 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.73552256979331 bayes_pls_golite062009
transcription factor binding 0.53246783159686 bayes_pls_golite062009
sequence-specific DNA binding 0.52093073106685 bayes_pls_golite062009
transcription corepressor activity 0.503526851907562 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [825-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AELQPHHRMP DPVREDIAST PSAVGPYDAA SITKTTSNSA FTPINSMPPH LNSLSHHPMA  60
   61 QRPYLYDAIS FPNKNVNQNN ANAFPNQLIS LHQIRNYAHQ PAGLMAGEHL LGVSVGPGKD 120
  121 KG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle