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View Structure Prediction Details

Protein: toy-PA
Organism: Drosophila melanogaster
Length: 543 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for toy-PA.

Description E-value Query
Range
Subject
Range
gi|76666878 - gi|76666878|ref|XP_877534.1| PREDICTED: similar to Paired box protein Pax-3 isoform 10 [Bos taurus]
282.0 [0..1] [316..4]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLTTEHIMH GHPHSSVGQS TLFGCSTAGH SGINQLGGVY VNGRPLPDST RQKIVELAHS  60
   61 GARPCDISRI LQVSNGCVSK ILGRYYETGS IKPRAIGGSK PRVATTPVVQ KIADYKRECP 120
  121 SIFAWEIRDR LLSEQVCNSD NIPSVSSINR VLRNLASQKE QQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.522879
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [163-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQQQNESVYE KLRMFNGQTG GWAWYPSNTT TAHLTLPPAA SVVTSPANLS GQADRDDVQK  60
   61 RELQFSVEVS HTNSHDSTSD GNSEHNSSGD EDSQMRLRLK RKLQRNRTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [272-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSNEQIDSLE KEFERTHYPD VFARERLADK IGLPEARIQV WFSNRRAKWR REEKMRTQRR  60
   61 SA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [334-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTVDGSGRTS TANNPSGTTA SSSVATSNNS TPGIVNSAIN VAERTSSALV SNSLPEASNG  60
   61 PTVLGGEANT THTSSESPPL QPAAPRLPLN SGFNTMYSSI PQPIATMAEN YNSSLGSMTP 120
  121 SCLQQRDAYP YMFHDPLSLG SPYVSAHHRN TACNPSAAHQ QPPQHGVYTN SSPMPSSNTG 180
  181 VISAGVSVPV QISTQNVSDL TGSNYWPRLQ 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.96
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle