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View Structure Prediction Details

Protein: Psi-PC
Organism: Drosophila melanogaster
Length: 797 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Psi-PC.

Description E-value Query
Range
Subject
Range
gi|68365020 - gi|68365020|ref|XP_689672.1| PREDICTED: similar to KH-type splicing regulatory protein (FUSE binding...
318.0 [0..11] [689..324]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDFQQQGIN QSQALAQAIQ RAKQIAAKIQ PSQQGGGTAG PSPPSSGGGP GFKRINDDGD  60
   61 SGPESKRSLG SPEYANNSSN MSSGSGGGGG GGGGPGGASI TQAIAQAAAV AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [113-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLAASAGTSC EEQIRLPESV AGAFMGRSSN DTITHIQAES GVKVQVMQDQ DRVIMLRGQR  60
   61 DTVTKGREMI QNMANRAGGG QVEVLLTINM PPPGPSGYPP YQEIMIPGAK VGLVIGKGGD 120
  121 TIKQLQEKTG AKMIIIQDGP NQELIKPLRI SGEAQKIEHA KQMVLDLIAQ KDAQGQQQGG 180
  181 RGGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 2annA
Description: No description for 2annA was found.

Predicted Domain #3
Region A:
Residues: [297-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGPGMGF NNFNNGNGGE STEVFVPKIA VGVVIGKGGD MIRKIQTECG CKLQFIQGKN  60
   61 DEMGDRRCVI QGTRQQVDDA KRTIDGLIEN VMQRNGMNRN GNGGGGGPGG DSGNSNYGYG 120
  121 YGVNHAQGGR EEITFLVPAS KCGIVIGRGG ETIKLINQQS GAHTEMDRNA SNPPNEKLFK 180
  181 SKGTTDQVEA ARQMISEKIN MELNVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1j4wA
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
4.82131641133915 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription repressor activity 1.87340518658135 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [503-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRKPIGGGPG GGGGNSGGGQ NNSHHNQQQG GYGGQNQMQG GDPNSGAGYQ QQPWGGPYGQ  60
   61 QGWDPSGQQQ QMAMANQGGS AAGGASGGQD YSAQWIEYYK QMGCHREAEM IEQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [616-797]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMKAKQAGGS SGPVQQQQPQ QQQQSQQQTG GAGAGGADYS AQWAEYYRSV GKIEEAEAIE  60
   61 KTLKNKQQNG SGGQSSTPNP SQGGSGQQQP NPAAAAAAAA AAAAAAGGYG QSMTPTQYAQ 120
  121 YSQYYAAAAA AGGQPQGAPQ PGGGQSGGPP GNYPGNYPGA GYGGYPGAPG QQQQKSHKND 180
  181 NH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle