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View Structure Prediction Details

Protein: gro-PE
Organism: Drosophila melanogaster
Length: 730 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gro-PE.

Description E-value Query
Range
Subject
Range
gi|109111874 - gi|109111874|ref|XP_001102218.1| PREDICTED: transducin-like enhancer of split 4 (E(sp1) homolog, Dro...
577.0 [0..1] [730..8]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ  60
   61 RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120
  121 LNLIIGHQQQ HGIQQLLQQI HAQQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 89.481486
Match: PF03920.6
Description: No description for PF03920.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [145-646]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGGPPQPMG ALNPFGALGA TMGLPHGPQG LLNKPPEHHR PDIKPTGLEG PAAAEERLRN  60
   61 SVSPADREKY RTRSPLDIEN DSKRRKDEKL QEDEGEKSDQ DLVVDVANEM ESHSPRPNGE 120
  121 HVSMEVRDRE SLNGERLEKP SSSGIKQERP PSRSGSSSSR STPSLKTKDM EKPGTPGAKA 180
  181 RTPTPNAAAP APGVNPKQMM PQGPPPAGYP GAPYQRPADP YQRPPSDPAY GRPPPMPYDP 240
  241 HAHVRTNGIP HPSALTGGKP AYSFHMNGEG SLQPVPFPPD ALVGVGIPRH ARQINTLSHG 300
  301 EVVCAVTISN PTKYVYTGGK GCVKVWDISQ PGNKNPVSQL DCLQRDNYIR SVKLLPDGRT 360
  361 LIVGGEASNL SIWDLASPTP RIKAELTSAA PACYALAISP DSKVCFSCCS DGNIAVWDLH 420
  421 NEILVRQFQG HTDGASCIDI SPDGSRLWTG GLDNTVRSWD LREGRQLQQH DFSSQIFSLG 480
  481 YCPTGDWLAV GMENSHVEVL HA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 2.60028864890135 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
G-protein-coupled receptor binding 1.39923391651476 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
cytoskeletal protein binding 0.900963766598159 bayes_pls_golite062009
actin binding 0.708446291495757 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
receptor binding 0.316169754698691 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
0.0430091774124504 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [647-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPDKYQLHL HESCVLSLRF AACGKWFVST GKDNLLNAWR TPYGASIFQS KETSSVLSCD  60
   61 ISTDDKYIVT GSGDKKATVY EVIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.522879
Match: 1gxrA
Description: Groucho/tle1, C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle