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View Structure Prediction Details

Protein: foxo-PC, foxo-PB
Organism: Drosophila melanogaster
Length: 613 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for foxo-PC, foxo-PB.

Description E-value Query
Range
Subject
Range
gi|40217297, gi|... - gi|4808164|emb|CAB42795.1| largest subunit of the RNA polymerase II complex [Drosophila guanche], gi...
159.0 [0..210] [612..1484]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDGYAQEWP RLTHTDNGLA MDQLGGDLPL DVGFEPQTRA RSNTWPCPRP ENFVEPTDEL  60
   61 DSTKASNQQL APGDSQQAIQ NANAAKKNSS RRNAWGNLSY ADLITHAIGS ATDKRLTLSQ 120
  121 IYEWMVQNVP YFKDKGDSNS SAGWKNSIRH NLSLHNRFMR VQNEGTGKSS WWMLNPEAKP 180
  181 GKSVRRRAAS METSRYEKRR GR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1e17A
Description: Afx (Foxo4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
structure-specific DNA binding 0.217544912085963 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [203-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKKRVEALRQ AGVVGLNDAT PSPSSSVSEG LDHFPESPLH SGGGFQLSPD FRQRASSNAS  60
   61 SCGRLSPIRA QDLEPDWGFP VDYQNTTMTQ AHAQALEELT GTMADELTLC NQQQQGFSAA 120
  121 SGLPSQPPPP PYQPPQHQQA QQQQQQQSPY ALNGPASGYN TLQPQSQCLL HRSLNCSCMH 180
  181 NARDGLSPNS VTTTMSPAYP NSEPSSDSLN TYSNVVLDGP ADTAALMVQQ QQQQQQQQQL 240
  241 SASLEGQCLE VLNNEAQPID EFNLENFPVG NLECNVEELL QQEMSYGGLL DINIPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [499-613]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATVNTNLVNS SSGPLSISNI SNLSNISSNS GSSLSLNQLQ AQLQQQQQQQ QAQQQQQAQQ  60
   61 QQQQHQQHQQ QLLLNNNNNS SSSLELATQT ATTNLNARVQ YSQPSVVTSP PSWVH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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