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View Structure Prediction Details

Protein: AP-1gamma-PB
Organism: Drosophila melanogaster
Length: 976 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AP-1gamma-PB.

Description E-value Query
Range
Subject
Range
gi|71834186 - gi|71834186|gb|AAZ41765.1| RE56180p [Drosophila melanogaster]
661.0 [0..1] [976..1]

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Predicted Domain #1
Region A:
Residues: [1-691]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPYYEQDWS VLPPENNRRF NPAFNMATIR QAFTEAVERV RMPTPTRLRD LIRQIRAART  60
   61 AAEERAVVNK ECAYIRSTFR EEDSVWRCRN IAKLLYIHML GYPAHFGQLE CLKLTASTRF 120
  121 TDKRIGYLGA MLLLDERQDV HLLITNCLKN DLNSSTQFVV GLALCTLGAI ASPEMARDLA 180
  181 SEVERLMKSP NTYIRKKATL CAFRVIRRVP ELMEIFLPAT RSLLSEKNHG ILITGVTLIT 240
  241 EMCENSSDTL MHFKKIVPNL VRILKNLILG GYSPEHDVSG VSDPFLQVKI LRLLRILGHN 300
  301 DPDASEAMND ILAQVATNTE TSKNVGNTIL YETVLSIMDI RSEGGLRVLA VNILGRFLLN 360
  361 SDKNIRYVAL NTLLRTVHAD TSAVQRHRTT ILECLKDPDV SIRRRAMELS FALINAQNIR 420
  421 TMTKELLLFL EKADAEFKAQ CSSGMILAAE RYSPTTRWHL DTQLSVLIAA GNYVRDDVVS 480
  481 STIQLVSSSP VPEQTYITNR FWESLQVANH CEDKQPLLQV AVWAIGEYGD LFMYGANEDE 540
  541 FERPTESDLI AVYYKFLTSA QVSTTSKQYA LVSLAKLSTR LQQCVEEIQA LITSFGSHLN 600
  601 VDLQQRGVEF TQLFGHYKHL RPPLLEKMPA MQISRISSQN GESGGGSFDD NSPDVIENGV 660
  661 EGGGGGGHSL IESNMNTLGD NTNILLDLLG S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 152.0
Match: 1w63A
Description: AP1 clathrin adaptor core
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [692-803]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDLSAGGAGD LVAATDLSNA VHKKNSRNAN DVVAPVSNNQ DLLDLLDLDL SAPSSTTTGA  60
   61 PAGGGGGGGI VALVGDNNQS SAANMNNMLG GLDLGGFGSG LDSSASIPTN GN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [804-976]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLASMLGGLG APPAASPSLA ASAPVGNLID GHAGSLLADL NPTAASNNVV VPPQGPRLTA  60
   61 LDKDGLLVQL VSVRGSDCMR IYMTTTNNSD NTLDQYLLQA AVQRSFQLQM LTPSGSVLPP 120
  121 GGVITQEMRV VATSNATLRM RLRIQYVLDG QQQVEQTEVS GFPEQQPAPA AAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 1iu1A
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.73706375360191 bayes_pls_golite062009
protein binding 1.07977592306595 bayes_pls_golite062009
transporter activity 0.169557557237959 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle