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View Structure Prediction Details

Protein: EMX1_MOUSE
Organism: Mus musculus
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109103362 - gi|109103362|ref|XP_001103417.1| PREDICTED: similar to empty spiracles homolog 1 [Macaca mulatta]
EMX1 - empty spiracles homeobox 1
gi|208966206 - gi|208966206|dbj|BAG73117.1| empty spiracles homeobox 1 [synthetic construct]
157.0 [0..1] [257..1]
gi|76628915 - gi|76628915|ref|XP_586475.2| PREDICTED: similar to empty spiracles homolog 1 [Bos taurus]
155.0 [0..1] [257..1]
gi|109473809, gi... - gi|109473809|ref|XP_001073769.1| PREDICTED: similar to empty spiracles homolog 1 [Rattus norvegicus]...
155.0 [0..1] [257..1]
gi|119620162, gi... - gi|94536800|ref|NP_004088.2| empty spiracles homolog 1 [Homo sapiens], gi|119620162|gb|EAW99756.1| e...
155.0 [0..1] [257..34]
gi|21902136 - gi|21902136|gb|AAM78420.1| Emx3 [Scyliorhinus canicula]
130.0 [0..1] [257..1]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
129.0 [0..7] [228..1]
gi|47228655 - gi|47228655|emb|CAG07387.1| unnamed protein product [Tetraodon nigroviridis]
127.0 [0..1] [228..1]
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
126.0 [0..7] [234..1]
gi|1334651 - gi|1334651|emb|CAA30124.1| unnamed protein product [Xenopus laevis]
126.0 [0..159] [248..3]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAAKRGF TIESLVAKDG GTGGSPGSGG AGSHPLAVAA SEEPLRPTAL NYPHPSAAET  60
   61 AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGSSSLQP PHSFFSAQHR 120
  121 DPLHF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [126-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPWVLRNRFF GHRFQASDVP QDGLLLHGPF ARKPKRIRTA FSPSQLLRLE RAFEKNHYVV  60
   61 GAERKQLAGS LSLSETQVKV WFQNRRTKYK RQKLEEEGPE SEQKKKGSHH INRWRIATKQ 120
  121 ANGEDIDVTS ND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.30103
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle