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View Structure Prediction Details

Protein: gi|42403585
Organism: Homo sapiens
Length: 372 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|42403585.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
0.0 [1..371] [2507..2864]
gi|76620961 - gi|76620961|ref|XP_589359.2| PREDICTED: similar to zinc finger protein 354B [Bos taurus]
0.0 [1..367] [345..691]
gi|2224593 - gi|2224593|dbj|BAA20784.1| KIAA0326 [Homo sapiens]
0.0 [1..371] [223..580]
gi|114679322 - gi|114679322|ref|XP_512927.2| PREDICTED: zinc finger protein 71 [Pan troglodytes]
0.0 [1..365] [318..662]
gi|109128254 - gi|109128254|ref|XP_001102645.1| PREDICTED: similar to zinc finger protein 629 [Macaca mulatta]
0.0 [1..371] [216..573]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRRGFSRAG AAQRSTRPAA EPQPPAARAL QPRPGVPGPL RCREYLQPPA PRREAEGLSH  60
   61 QGSEVGAESG ARPKERGAEP ELGRLVAEKP GVKMTERFDC HHCNESLFGK KYILREESPY 120
  121 CVVCFETLFA NTCEECGKPI GCDCKDLSYK DRHWHEACFH CSQCRNSLVD KPFAAKEDQL 180
  181 LCTDCYSNEY SSKCQECKKT IMPGTRKMEY KGSSWHETCF IC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.09691
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [223-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRCQQPIGTK SFIPKDNQNF CVPCYEKQHA MQCVQCKKPI TTGGVTYREQ PWHKECFVCT  60
   61 ACRKQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
cytoskeletal protein binding 2.22104591928521 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
molecular transducer activity 1.12277938241964 bayes_pls_golite062009
signal transducer activity 1.12277938241964 bayes_pls_golite062009
structure-specific DNA binding 0.93314267845352 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
tubulin binding 0.744315484113484 bayes_pls_golite062009
microtubule binding 0.576452165256057 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
receptor activity 0.36635758793995 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [289-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGQRFTARDD FAYCLNCFCD LYAKKCAGCT NPISGLGGTK YISFEERQWH NDCFNCKKCS  60
   61 LSLVGRGFLT ERDDILCPDC GKDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 2egqA
Description: No description for 2egqA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle