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View Structure Prediction Details

Protein: gi|34531663, gi|...
Organism: Homo sapiens
Length: 548 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|34531663, gi|....

Description E-value Query
Range
Subject
Range
gi|114666652 - gi|114666652|ref|XP_001139088.1| PREDICTED: Rho GTPase activating protein 27 isoform 6 [Pan troglody...
4.0E-95 [1..548] [1..549]
gi|197099036 - gi|197099036|ref|NP_001126219.1| Rho GTPase activating protein 27 [Pongo abelii]
gi|55730739 - gi|55730739|emb|CAH92090.1| hypothetical protein [Pongo abelii]
7.0E-95 [1..548] [1..549]
gi|109116371 - gi|109116371|ref|XP_001115580.1| PREDICTED: similar to Rho GTPase activating protein 27 isoform 2 [M...
1.0E-93 [1..548] [139..686]
gi|73487328 - gi|73487328|gb|AAI01392.2| ARHGAP27 protein [Homo sapiens]
3.0E-87 [1..548] [73..593]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPGLSPGSP GDPRPPTPET DYPESLTSYP EEDYSPVGSF GEPGPTSPLT TPPGWSCHVS  60
   61 QDKQMLYTNH FTQEQWVRLE DPHGKPYFYN PEDSSVRWEL PQVPVPAPRS IHKSSQDGDT 120
  121 PAQASPPEEK VPAELDEVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1u5eA
Description: Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [140-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWEEVSPATA AVRTKTLDKA GVLHRTKTAD KGKRLRKKHW SASWTVLEGG VLTFFKDSKT  60
   61 SAAGGLRQPS KFSTPEYTVE LRGATLSWAP KDKSSRKNVL ELRSRDGSEY LIQHDSEAII 120
  121 STWHKAIAQG IQELSAELPP EESESSRVDF GSSERLGSWQ EKEEDARPNA AAPALGPVGL 180
  181 ESDLSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA ALCERERSRV PRFVQQCIRA 240
  241 VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR WEDVHVITGA LKLFFRELPE 300
  301 PLFPFSHFRQ FIAAIKLQDQ ARRSRCVRDL VRSLPAPNHD TLRMLFQHLC RVIEHGEQNR 360
  361 MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ QCADIFPPH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme activator activity 0.981276523918403 bayes_pls_golite062009
GTPase activator activity 0.961835976057597 bayes_pls_golite062009
Ras GTPase activator activity 0.532077307020219 bayes_pls_golite062009
binding 0.511421075674542 bayes_pls_golite062009
Rho GTPase activator activity 0.305942003431746 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle