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View Structure Prediction Details

Protein: OGT
Organism: Homo sapiens
Length: 1046 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OGT.

Description E-value Query
Range
Subject
Range
gi|76659275 - gi|76659275|ref|XP_872371.1| PREDICTED: similar to O-linked GlcNAc transferase isoform 1 isoform 3 [...
0.0 [1..1046] [1..1046]
OGT1_MOUSE - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Mus musculus GN=...
0.0 [1..1046] [1..1046]
OGT1_PIG - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Sus scrofa GN=OG...
0.0 [1..1046] [1..1046]
gi|74007670 - gi|74007670|ref|XP_849392.1| PREDICTED: similar to O-linked GlcNAc transferase isoform 1 isoform 2 [...
0.0 [1..1046] [1..1046]
gi|31873825 - gi|31873825|emb|CAD97853.1| hypothetical protein [Homo sapiens]
0.0 [1..1046] [1..1046]

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Predicted Domain #1
Region A:
Residues: [1-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSVGNVAD STEPTKRMLS FQGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL  60
   61 LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP 120
  121 DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY 180
  181 LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKAVTL DPNFLDAYIN LGNVLKEARI 240
  241 FDRAVAAYLR ALSLSPNHAV VHGNLACVYY EQGLIDLAID TYRRAIELQP HFPDAYCNLA 300
  301 NALKEKGSVA EAEDCYNTAL RLCPTHADSL NNLANIKREQ GNIEEAVRLY RKALEVFPEF 360
  361 AAAHSNLASV LQQQGKLQEA LMHYKEAIRI SPTFADAYSN MGNTLKEMQD VQGALQCYTR 420
  421 AIQIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.0
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.71974493738804 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.48921024987872 bayes_pls_golite062009
phosphatase activity 2.4502869290841 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.38923256228405 bayes_pls_golite062009
hydrolase activity 2.16486484513356 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.07186557005331 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
protein serine/threonine phosphatase activity 0.949260584741775 bayes_pls_golite062009
transcription regulator activity 0.897652181945102 bayes_pls_golite062009
nucleic acid binding 0.89107071408431 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.78476205818302 bayes_pls_golite062009
signal sequence binding 0.71760275307167 bayes_pls_golite062009
DNA binding 0.69174990631975 bayes_pls_golite062009
transferase activity 0.127854220687373 bayes_pls_golite062009
transcription factor activity 0.0355464132591463 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [426-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAFADAHSNL ASIHKDSGNI PEAIASYRTA LKLKPDFPDA YCNLAHCLQI VCDWTDYDER  60
   61 MKKLVSIVAD QLEKNRLPSV HPHHSMLYPL SHGFRKAIAE RHGNLCLDKI NVLHKPPYEH 120
  121 PKDLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 2q7fA
Description: No description for 2q7fA was found.

Predicted Domain #3
Region A:
Residues: [551-644]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDGRLRVGY VSSDFGNHPT SHLMQSIPGM HNPDKFEVFC YALSPDDGTN FRVKVMAEAN  60
   61 HFIDLSQIPC NGKAADRIHQ DGIHILVNMN GYTK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [645-702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GARNELFALR PAPIQAMWLG YPGTSGALFM DYIITDQETS PAEVAEQYSE KLAYMPHT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [703-803]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FFIGDHANMF PHLKKKAVID FKSNGHIYDN RIVLNGIDLK AFLDSLPDVK IVKMKCPDGG  60
   61 DNADSSNTAL NMPVIPMNTI AEAVIEMINR GQIQITINGF S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [804-1046]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISNGLATTQI NNKAATGEEV PRTIIVTTRS QYGLPEDAIV YCNFNQLYKI DPSTLQMWAN  60
   61 ILKRVPNSVL WLLRFPAVGE PNIQQYAQNM GLPQNRIIFS PVAPKEEHVR RGQLADVCLD 120
  121 TPLCNGHTTG MDVLWAGTPM VTMPGETLAS RVAASQLTCL GCLELIAKNR QEYEDIAVKL 180
  181 GTDLEYLKKV RGKVWKQRIS SPLFNTKQYT MELERLYLQM WEHYAAGNKP DHMIKPVEVT 240
  241 ESA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 2gejA
Description: No description for 2gejA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle