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View Structure Prediction Details

Protein: gi|62822535, gi|...
Organism: Homo sapiens
Length: 1230 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|62822535, gi|....

Description E-value Query
Range		 Subject
Range
gi|162318718, gi... - gi|162318718|gb|AAI56939.1| Otoferlin [synthetic construct], gi|162317976|gb|AAI56052.1| Otoferlin [...
gi|35493860 - gi|35493860|ref|NP_919304.1| otoferlin isoform d [Homo sapiens]
 0.0 [1..1230] [1..1230]
OTOF_RAT - Otoferlin OS=Rattus norvegicus GN=Otof PE=1 SV=2
 0.0 [1..1230] [763..1993]
gi|10119912 - gi|10119912|gb|AAG12989.1|AF183183_1 cochlear otoferlin [Mus musculus]
 0.0 [1..1230] [762..1992]
gi|73979879 - gi|73979879|ref|XP_859651.1| PREDICTED: similar to otoferlin isoform b isoform 3 [Canis familiaris]
 0.0 [1..1230] [1..1230]

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Predicted Domain #1
Region A:
Residues: [1-196] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTEKSYPE RRLRGVLEEL SCGCCRFLSL ADKDQGHSSR TRLDRERLKS CMRELENMGQ  60
   61 QARMLRAQVK RHTVRDKLRL CQNFLQKLRF LADEPQHSIP DIFIWMMSNN KRVAYARVPS 120
  121 KDLLFSIVEE ETGKDCAKVK TLFLKLPGKR GFGSAGWTVQ AKVELYLWLG LSKQRKEFLC 180
  181 GLPCGFQEVK AAQGLG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 1sl6A
Description: Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [197-328] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHAFPPVSLV YTKKQAFQLR AHMYQARSLF AADSSGLSDP FARVFFINQS QCTEVLNETL  60
   61 CPTWDQMLVF DNLELYGEAH ELRDDPPIIV IEIYDQDSMG KADFMGRTFA KPLVKMADEA 120
  121 YCPPRFPPQL EY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.39794
Match: 1dqvA
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [329-830] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQIYRGNATA GDLLAAFELL QIGPAGKADL PPINGPVDVD RGPIMPVPMG IRPVLSKYRV  60
   61 EVLFWGLRDL KRVNLAQVDR PRVDIECAGK GVQSSLIHNY KKNPNFNTLV KWFEVDLPEN 120
  121 ELLHPPLNIR VVDCRAFGRY TLVGSHAVSS LRRFIYRPPD RSAPSWNTTG EVVVTMEPEV 180
  181 PIKKLETMVK LDATSEAVVK VDVAEEEKEK KKKKKGTAEE PEEEEPDESM LDWWSKYFAS 240
  241 IDTMKEQLRQ QEPSGIDLEE KEEVDNTEGL KGSMKGKEKA RAAKEEKKKK TQSSGSGQGS 300
  301 EAPEKKKPKI DELKVYPKEL ESEFDNFEDW LHTFNLLRGK TGDDEDGSTE EERIVGRFKG 360
  361 SLCVYKVPLP EDVSREAGYD STYGMFQGIP SNDPINVLVR VYVVRATDLH PADINGKADP 420
  421 YIAIRLGKTD IRDKENYISK QLNPVFGKSF DIEASFPMES MLTVAVYDWD LVGTDDLIGE 480
  481 TKIDLENRFY SKHRATCGIA QT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 1djgA
Description: Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.693222330136336 bayes_pls_golite062009
hydrolase activity 0.17768980721334 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.05056572092175 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.0304825793447705 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.01534375493934 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [831-943] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSTHGYNIWR DPMKPSQILT RLCKDGKVDG PHFGPPGRVK VANRVFTGPS EIEDENGQRK  60
   61 PTDEHVALLA LRHWEDIPRA GCRLVPEHVE TRPLLNPDKP GIEQGRLELW VDM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.974
Match: 2cpnA
Description: Solution structure of the second dsRBD of TAR RNA-binding protein 2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [944-1108] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPMDMPAPGT PLDISPRKPK KYELRVIIWN TDEVVLEDDD FFTGEKSSDI FVRGWLKGQQ  60
   61 EDKQDTDVHY HSLTGEGNFN WRYLFPFDYL AAEEKIVISK KESMFSWDET EYKIPARLTL 120
  121 QIWDADHFSA DDFLGAIELD LNRFPRGAKT AKQCTMEMAT GEVDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2b3rA
Description: Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1109-1230] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLVSIFKQKR VKGWWPLLAR NENDEFELTG KVEAELHLLT AEEAEKNPVG LARNEPDPLE  60
   61 KPNRPDTSFI WFLNPLKSAR YFLWHTYRWL LLKLLLLLLL LLLLALFLYS VPGYLVKKIL 120
  121 GA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 2dmhA
Description: No description for 2dmhA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle