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Protein Overview: gi|35493860

General Information:
Name(s) found: gi|35493860 [NCBI NR]
Description(s) found:
Found 12 descriptions.
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  • gi|35493860|ref|NP_919304.1| otoferlin isoform d [Homo sapiens] [NCBI NR]
    • Organism: Homo sapiens
    Length: 1230 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTEKSYPE RRLRGVLEEL SCGCCRFLSL ADKDQGHSSR TRLDRERLKS CMRELENMGQ  60
   61 QARMLRAQVK RHTVRDKLRL CQNFLQKLRF LADEPQHSIP DIFIWMMSNN KRVAYARVPS 120
  121 KDLLFSIVEE ETGKDCAKVK TLFLKLPGKR GFGSAGWTVQ AKVELYLWLG LSKQRKEFLC 180
  181 GLPCGFQEVK AAQGLGLHAF PPVSLVYTKK QAFQLRAHMY QARSLFAADS SGLSDPFARV 240
  241 FFINQSQCTE VLNETLCPTW DQMLVFDNLE LYGEAHELRD DPPIIVIEIY DQDSMGKADF 300
  301 MGRTFAKPLV KMADEAYCPP RFPPQLEYYQ IYRGNATAGD LLAAFELLQI GPAGKADLPP 360
  361 INGPVDVDRG PIMPVPMGIR PVLSKYRVEV LFWGLRDLKR VNLAQVDRPR VDIECAGKGV 420
  421 QSSLIHNYKK NPNFNTLVKW FEVDLPENEL LHPPLNIRVV DCRAFGRYTL VGSHAVSSLR 480
  481 RFIYRPPDRS APSWNTTGEV VVTMEPEVPI KKLETMVKLD ATSEAVVKVD VAEEEKEKKK 540
  541 KKKGTAEEPE EEEPDESMLD WWSKYFASID TMKEQLRQQE PSGIDLEEKE EVDNTEGLKG 600
  601 SMKGKEKARA AKEEKKKKTQ SSGSGQGSEA PEKKKPKIDE LKVYPKELES EFDNFEDWLH 660
  661 TFNLLRGKTG DDEDGSTEEE RIVGRFKGSL CVYKVPLPED VSREAGYDST YGMFQGIPSN 720
  721 DPINVLVRVY VVRATDLHPA DINGKADPYI AIRLGKTDIR DKENYISKQL NPVFGKSFDI 780
  781 EASFPMESML TVAVYDWDLV GTDDLIGETK IDLENRFYSK HRATCGIAQT YSTHGYNIWR 840
  841 DPMKPSQILT RLCKDGKVDG PHFGPPGRVK VANRVFTGPS EIEDENGQRK PTDEHVALLA 900
  901 LRHWEDIPRA GCRLVPEHVE TRPLLNPDKP GIEQGRLELW VDMFPMDMPA PGTPLDISPR 960
  961 KPKKYELRVI IWNTDEVVLE DDDFFTGEKS SDIFVRGWLK GQQEDKQDTD VHYHSLTGEG1020
 1021 NFNWRYLFPF DYLAAEEKIV ISKKESMFSW DETEYKIPAR LTLQIWDADH FSADDFLGAI1080
 1081 ELDLNRFPRG AKTAKQCTME MATGEVDVPL VSIFKQKRVK GWWPLLARNE NDEFELTGKV1140
 1141 EAELHLLTAE EAEKNPVGLA RNEPDPLEKP NRPDTAFVWF LNPLKSIKYL ICTRYKWLII1200
 1201 KIVLALLGLL MLGLFLYSLP GYMVKKLLGA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] FFAS03 1.01 Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
    2 View Details [195..310] PSI-BLAST 51.39794 Synaptogamin I
    3 View Details [311..834] PSI-BLAST 31.69897 No description for 2fjuB was found.
    4 View Details [835..927] deduced N/A No confident structure predictions are available.
    5 View Details [928..1108] PSI-BLAST 14.30103 Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2
    6 View Details [1109..1230] FFAS03 1.01 No description for 2dmhA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • catalytic activity
    		•  0.693222330136336 bayes_pls_golite062009
  • hydrolase activity
    		•  0.17768980721334 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.05056572092175 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.0304825793447705 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.01534375493934 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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