YRC Public Data Repository - Protein Structure Prediction

Protein:	YIHQ_ECOLI
Organism:	Escherichia coli
Length:	678 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YIHQ_ECOLI.

Description	E-value	Query Range	Subject Range
LYAG_MOUSE - Lysosomal alpha-glucosidase OS=Mus musculus GN=Gaa PE=1 SV=2	539.0	[0..4]	[677..131]
gi\|30064833, gi\|... - gi\|30064833\|ref\|NP_839004.1\| alpha-glucosidase [Shigella flexneri 2a str. 2457T], gi\|30043093\|gb\|AAP... gi\|110616984, gi... - gi\|110807436\|ref\|YP_690956.1\| alpha-glucosidase [Shigella flexneri 5 str. 8401], gi\|110616984\|gb\|ABF...	533.0	[0..1]	[678..1]
gi\|109118860, gi... - gi\|109118860\|ref\|XP_001110024.1\| PREDICTED: acid alpha-glucosidase isoform 3 [Macaca mulatta], gi\|10...	532.0	[0..36]	[677..162]
LYAG_RAT - Lysosomal alpha-glucosidase OS=Rattus norvegicus GN=Gaa PE=2 SV=1	532.0	[0..4]	[677..131]
gi\|56130122, gi\|... - gi\|56415865\|ref\|YP_152940.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Paratyph... gi\|197364794, gi... - gi\|197364794\|ref\|YP_002144431.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Para...	532.0	[0..1]	[678..1]
gi\|304982\|gb\|AAB... - ORF_f678 [Escherichia coli] gi\|304982 - gi\|304982\|gb\|AAB03011.1\| ORF_f678 [Escherichia coli]	532.0	[0..1]	[678..1]
gi\|24054446, gi\|... - gi\|24115168\|ref\|NP_709678.1\| alpha-glucosidase [Shigella flexneri 2a str. 301], gi\|24054446\|gb\|AAN45...	531.0	[0..1]	[678..1]
gi\|214002308 - gi\|214002308\|ref\|ZP_03413043.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Typhi... gi\|16504718, gi\|... - gi\|25512571\|pir\|\|AE0948 probable glycosyl hydrolase STY3859 [imported] - Salmonella enterica subsp. ... gi\|29143902, gi\|... - gi\|29143902\|ref\|NP_807244.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Typhi st... gi\|213647335 - gi\|213647335\|ref\|ZP_03377388.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Typhi... gi\|16762414 - gi\|16762414\|ref\|NP_458031.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Typhi st...	529.0	[0..1]	[678..1]
gi\|62130113, gi\|... - gi\|62182480\|ref\|YP_218897.1\| alpha-glucosidase [Salmonella enterica subsp. enterica serovar Cholerae... gi\|224585829, gi... - gi\|224585829\|ref\|YP_002639628.1\| putative glycosyl hydrolase [Salmonella enterica subsp. enterica se...	529.0	[0..1]	[678..1]

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Predicted Domain #1

Region A:
Residues: [1-678]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTPRPQLLD FQFHQNNDSF TLHFQQRLIL THSKDNPCLW IGSGIADIDM FRGNFSIKDK  60
   61 LQEKIALTDA IVSQSPDGWL IHFSRGSDIS ATLNISADDQ GRLLLELQND NLNHNRIWLR 120
  121 LAAQPEDHIY GCGEQFSYFD LRGKPFPLWT SEQGVGRNKQ TYVTWQADCK ENAGGDYYWT 180
  181 FFPQPTFVST QKYYCHVDNS CYMNFDFSAP EYHELALWED KATLRFECAD TYISLLEKLT 240
  241 ALLGRQPELP DWIYDGVTLG IQGGTEVCQK KLDTMRNAGV KVNGIWAQDW SGIRMTSFGK 300
  301 RVMWNWKWNS ENYPQLDSRI KQWNQEGVQF LAYINPYVAS DKDLCEEAAQ HGYLAKDASG 360
  361 GDYLVEFGEF YGGVVDLTNP EAYAWFKEVI KKNMIELGCG GWMADFGEYL PTDTYLHNGV 420
  421 SAEIMHNAWP ALWAKCNYEA LEETGKLGEI LFFMRAGSTG SQKYSTMMWA GDQNVDWSLD 480
  481 DGLASVVPAA LSLAMTGHGL HHSDIGGYTT LFEMKRSKEL LLRWCDFSAF TPMMRTHEGN 540
  541 RPGDNWQFDG DAETIAHFAR MTTVFTTLKP YLKEAVALNA KSGLPVMRPL FLHYEDDAHT 600
  601 YTLKYQYLLG RDILVAPVHE EGRSDWTLYL PEDNWVHAWT GEAFRGGEVT VNAPIGKPPV 660
  661 FYRADSEWAA LFASLKSI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	128.0
Match:	1we5A
Description:	Crystal Structure of Alpha-Xylosidase from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.32563207632796	bayes_pls_golite062009
hydrolase activity	0.85514037342026	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	0.80912338090552	bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds	0.41375210927547	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: