YRC Public Data Repository - Protein Structure Prediction

Protein:	MDTE_ECOLI, YHIU...
Organism:	Escherichia coli
Length:	385 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDTE_ECOLI, YHIU....

Description	E-value	Query Range	Subject Range
gi\|168746950, gi... - gi\|188018287\|gb\|EDU56409.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4113]... gi\|189359048, gi... - gi\|189359048\|gb\|EDU77467.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4401]... gi\|25391617, gi\|... - pir\|\|B86024 probable membrane protein yhiU [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|12518222, gi\|... - gi\|15804057\|ref\|NP_290093.1\| multidrug resistance efflux protein MdtE [Escherichia coli O157:H7 EDL9... MDTE_ECO57 - Multidrug resistance protein MdtE OS=Escherichia coli O157:H7 GN=mdtE PE=3 SV=1 gi\|208733245, gi... - gi\|208811968\|ref\|ZP_03253297.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4... gi\|208739922, gi... - gi\|208819799\|ref\|ZP_03260119.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4... gi\|209159909, gi... - gi\|209398509\|ref\|YP_002272990.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC... gi\|217321414, gi... - gi\|217325193\|ref\|ZP_03441277.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. TW1... gi\|189374505, gi... - gi\|189374505\|gb\|EDU92921.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC869],... gi\|168797342, gi... - gi\|189379963\|gb\|EDU98379.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC508],... gi\|15833647, gi\|... - gi\|15833647\|ref\|NP_312420.1\| multidrug efflux system protein MdtE [Escherichia coli O157:H7 str. Sak... gi\|195935041 - gi\|195935041\|ref\|ZP_03080423.1\| multidrug resistance efflux protein MdtE [Escherichia coli O157:H7 s... gi\|208729177, gi... - gi\|208809376\|ref\|ZP_03251713.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4... gi\|168759595, gi... - gi\|189369775\|gb\|EDU88191.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4501]... gi\|254795465, gi... - gi\|254795465\|ref\|YP_003080302.1\| multidrug resistance efflux transporter [Escherichia coli O157:H7 s... gi\|189364742, gi... - gi\|189364742\|gb\|EDU83161.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4486]... gi\|168772535, gi... - gi\|187771435\|gb\|EDU35279.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4196]... gi\|189002231, gi... - gi\|189002231\|gb\|EDU71217.1\| multidrug resistance protein MdtE [Escherichia coli O157:H7 str. EC4076]...	300.0	[0..1]	[385..1]
gi\|91074593, gi\|... - gi\|91213019\|ref\|YP_543005.1\| multidrug resistance efflux protein MdtE [Escherichia coli UTI89], gi\|9... gi\|110345351, gi... - gi\|110643759\|ref\|YP_671489.1\| multidrug efflux system protein MdtE [Escherichia coli 536], gi\|110345... gi\|191170475, gi... - gi\|191170475\|ref\|ZP_03032028.1\| multidrug resistance protein MdtE [Escherichia coli F11], gi\|1909092... gi\|215488790, gi... - gi\|215488790\|ref\|YP_002331221.1\| multidrug efflux system protein MdtE [Escherichia coli O127:H6 str.... gi\|115514920, gi... - gi\|117625796\|ref\|YP_859119.1\| multidrug resistance efflux protein MdtE [Escherichia coli APEC O1], g... gi\|218367357, gi... - gi\|218560588\|ref\|YP_002393501.1\| multidrug efflux system protein MdtE [Escherichia coli S88], gi\|218... MDTE_ECOL6 - Multidrug resistance protein MdtE OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=... MDTE_ECOL6 - Multidrug resistance protein MdtE OS=Escherichia coli O6 GN=mdtE PE=2 SV=1 gi\|226902544, gi... - gi\|237703280\|ref\|ZP_04533761.1\| multidrug resistance efflux transporter [Escherichia sp. 3_2_53FAA],...	299.0	[0..1]	[385..1]
gi\|56384967 - gi\|56384967\|gb\|AAV85949.1\| AcrA [Morganella morganii]	297.0	[0..1]	[385..1]
gi\|112182847, gi... - gi\|148807119\|gb\|ABR13270.1\| AcrA [Enterobacter cloacae], gi\|112182847\|emb\|CAL18625.1\| AcrA protein [...	293.0	[0..1]	[384..1]
gi\|82778656, gi\|... - gi\|82778656\|ref\|YP_405005.1\| multidrug resistance efflux protein MdtE [Shigella dysenteriae Sd197], ...	293.0	[0..1]	[385..1]
gi\|36787147, gi\|... - gi\|37527711\|ref\|NP_931056.1\| acriflavin resistance protein A precursor [Photorhabdus luminescens sub...	290.0	[0..6]	[384..10]
gi\|78222029, gi\|... - gi\|78222029\|ref\|YP_383776.1\| secretion protein HlyD [Geobacter metallireducens GS-15], gi\|78193284\|g...	290.0	[0..2]	[384..3]
gi\|110804490, gi... - gi\|110804490\|ref\|YP_688010.1\| acriflavin resistance protein A [Shigella flexneri 5 str. 8401], gi\|11...	288.0	[0..1]	[383..13]
gi\|117622721, gi... - gi\|117622721\|ref\|YP_851634.1\| acriflavine resistance protein A precursor [Escherichia coli APEC O1],... gi\|222355825 - gi\|222355825\|gb\|ACM48570.1\| acriflavine resistance protein A [Escherichia coli] gi\|218698625, gi... - gi\|218698625\|ref\|YP_002406254.1\| multidrug efflux system [Escherichia coli IAI39], gi\|218368611\|emb\|... gi\|237707541, gi... - gi\|237707541\|ref\|ZP_04538022.1\| acriflavine resistance protein A [Escherichia sp. 3_2_53FAA], gi\|226... gi\|75238215 - gi\|75238215\|ref\|ZP_00722216.1\| COG0845: Membrane-fusion protein [Escherichia coli F11] gi\|218703746, gi... - gi\|218703746\|ref\|YP_002411265.1\| multidrug efflux system [Escherichia coli UMN026], gi\|218430843\|emb... gi\|227884525, gi... - gi\|227884525\|ref\|ZP_04002330.1\| acridine efflux pump [Escherichia coli 83972], gi\|227838611\|gb\|EEJ49... gi\|215263615, gi... - gi\|215485543\|ref\|YP_002327974.1\| multidrug efflux system [Escherichia coli O127:H6 str. E2348/69], g... gi\|218557373, gi... - gi\|218557373\|ref\|YP_002390286.1\| multidrug efflux system [Escherichia coli S88], gi\|218364142\|emb\|CA...	287.0	[0..1]	[383..1]

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Predicted Domain #1

Region A:
Residues: [1-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRRRKLLIP LLFCGAMLTA CDDKSAENAA AMTPEVGVVT LSPGSVNVLS ELPGRTVPYE  60
   61 VAEIRPQVGG IIIKRNFIEG DKVNQGDSLY QIDPAPLQAE LNSAKGSLAK ALSTASNARI 120
  121 TFNRQASLLK TNYVSRQDYD TARTQLNEAE ANVTVAKAAV EQATINLQYA NVTSPITGVS 180
  181 GKSSVTVGAL VTANQADSLV TVQRLDPIYV DLTQSVQDFL RMKEEVASGQ IKQVQGSTPV 240
  241 QLNLENGKRY SQTGTLKFSD PTVDETTGSV TLRAIFPNPN GDLLPGMYVT ALVDEGSRQN 300
  301 VLLVPQEGVT HNAQGKATAL ILDKDDVVQL REIEASKAIG DQWVVTSGLQ AGDRVIVSGL 360
  361 QRIRPGIKAR AISSSQENAS TESKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.0
Match:	1t5eA
Description:	The structure of MexA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	6.72943251269963	bayes_pls_golite062009
	6.35210689530056	bayes_pls_golite062009
	6.27508108329198	bayes_pls_golite062009
transporter activity	4.64829294279324	bayes_pls_golite062009
transmembrane transporter activity	3.3430410220484	bayes_pls_golite062009
protein transporter activity	2.78337364594901	bayes_pls_golite062009
substrate-specific transporter activity	2.32388774487807	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.892013812755237	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.729251657794536	bayes_pls_golite062009
ion transmembrane transporter activity	0.696350598512404	bayes_pls_golite062009
cation transmembrane transporter activity	0.560994844134224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: