YRC Public Data Repository - Protein Structure Prediction

Protein:	YFAX_ECOLI
Organism:	Escherichia coli
Length:	260 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFAX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77995476, gi\|... - gi\|78043361\|ref\|YP_360107.1\| IclR family transcriptional regulator [Carboxydothermus hydrogenoforman...	282.0	[0..7]	[252..10]
gi\|76589242, gi\|... - gi\|76795434\|ref\|ZP_00777807.1\| regulatory proteins, IclR [Thermoanaerobacter ethanolicus ATCC 33223]... gi\|241902590, gi... - gi\|241902590\|ref\|ZP_04787323.1\| transcriptional regulator, IclR family [Thermoanaerobacter brockii s...	276.0	[0..1]	[251..1]
gi\|149948938, gi... - gi\|77687227\|ref\|ZP_00802500.1\| regulatory proteins, IclR [Alkaliphilus metalliredigenes QYMF], gi\|77...	270.0	[0..4]	[253..2]
gi\|56379913, gi\|... - gi\|56420071\|ref\|YP_147389.1\| IclR family transcriptional regulator [Geobacillus kaustophilus HTA426]...	265.0	[0..1]	[256..4]
gi\|147676812, gi... - gi\|98659900\|dbj\|GAA02725.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476768...	262.0	[0..3]	[250..13]
gi\|39982384, gi\|... - gi\|39995621\|ref\|NP_951572.1\| IclR family transcriptional regulator [Geobacter sulfurreducens PCA], g...	258.0	[0..1]	[253..1]
KDGR_DICCH - Pectin degradation repressor protein KdgR OS=Dickeya chrysanthemi GN=kdgR PE=1 SV=2	258.0	[0..3]	[252..51]
gi\|145408989, gi... - gi\|82498737\|ref\|ZP_00884193.1\| regulatory proteins, IclR [Caldicellulosiruptor saccharolyticus DSM 8...	256.0	[0..2]	[244..1]
gi\|15614700, gi\|... - gi\|15614700\|ref\|NP_243003.1\| IclR family transcriptional regulator [Bacillus halodurans C-125], gi\|1... gi\|25298235 - pir\|\|A83917 transcription regulator (IclR family) BH2137 [imported] - Bacillus halodurans (strain C-...	255.0	[0..7]	[252..2]
gi\|110805380, gi... - gi\|110805380\|ref\|YP_688900.1\| putative regulator [Shigella flexneri 5 str. 8401], gi\|110614928\|gb\|AB...	255.0	[0..3]	[252..9]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLESSKVPAL TRAIDILNLI ARIGPCSAAT IIDTLGIPKS TAYLLLNELR RQRFLSLDHQ  60
   61 ENFCLWTRLV ELSGHALSKM DLRELARPRL TQLMDTTGLL CHLGIIDNGS AYYILKVESS 120
  121 ATISVRSHEG KSLSLYRSGI GKCLLAWQPA AVQQSIIEGL VWEQATPTTI THPQQLHEEL 180
  181 ARIRRQGWSY DNGEDYADVR CVAAPVFNAN NELTAAISVV GTRLQINEEY RDYLAGKAIA 240
  241 CARDISRLLG WKSPFDLQAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	1mkmA
Description:	Thanscriptional regulator IclR, N-terminal domain; Thanscriptional regulator IclR, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.80545151006505	bayes_pls_golite062009
DNA binding	2.12853183689157	bayes_pls_golite062009
nucleic acid binding	2.06466906422115	bayes_pls_golite062009
transcription factor activity	2.00805912336419	bayes_pls_golite062009
binding	1.3234252548847	bayes_pls_golite062009
transcription activator activity	0.53294679084865	bayes_pls_golite062009
sequence-specific DNA binding	0.53285802828572	bayes_pls_golite062009
catalytic activity	0.319188290441009	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: