YRC Public Data Repository - Protein Structure Prediction

Protein:	YEII_ECOLI
Organism:	Escherichia coli
Length:	362 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEII_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20515311, gi\|... - gi\|20806843\|ref\|NP_622014.1\| ribokinase family sugar kinase [Thermoanaerobacter tengcongensis MB4], ... gi\|20806843 - gi\|20806843\|ref\|NP_622014.1\| Sugar kinase, ribokinase family [Thermoanaerobacter tengcongensis MB4]	268.0	[0..1]	[362..3]
gi\|37528180, gi\|... - gi\|37528180\|ref\|NP_931525.1\| hypothetical protein plu4352 [Photorhabdus luminescens subsp. laumondii...	265.0	[0..1]	[360..1]
gi\|242232471, gi... - gi\|242255988\|ref\|ZP_04800886.1\| PfkB domain protein [Thermoanaerobacter sp. X513], gi\|242232471\|gb\|E... gi\|166853166, gi... - gi\|167038926\|ref\|YP_001661911.1\| ribokinase-like domain-containing protein [Thermoanaerobacter sp. X...	262.0	[0..1]	[362..16]
gi\|166857176, gi... - gi\|76795414\|ref\|ZP_00777787.1\| PfkB [Thermoanaerobacter ethanolicus ATCC 33223], gi\|76589222\|gb\|EAO6...	258.0	[0..1]	[362..16]
gi\|77978379, gi\|... - gi\|77978379\|ref\|ZP_00833809.1\| COG0524: Sugar kinases, ribokinase family [Yersinia intermedia ATCC 2...	256.0	[0..1]	[360..10]
gi\|81246033, gi\|... - gi\|82544622\|ref\|YP_408569.1\| hypothetical protein SBO_2167 [Shigella boydii Sb227], gi\|81246033\|gb\|A...	256.0	[0..1]	[362..1]
gi\|218361496, gi... - gi\|218554728\|ref\|YP_002387641.1\| hypothetical protein ECIAI1_2240 [Escherichia coli IAI1], gi\|218361... gi\|218352506, gi... - gi\|218695774\|ref\|YP_002403441.1\| hypothetical protein EC55989_2413 [Escherichia coli 55989], gi\|2183... gi\|209912878, gi... - gi\|209919619\|ref\|YP_002293703.1\| hypothetical protein ECSE_2428 [Escherichia coli SE11], gi\|20991287... gi\|193062274, gi... - gi\|75259632\|ref\|ZP_00730934.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli E22], gi\|... gi\|75234048, gi\|... - gi\|75234048\|ref\|ZP_00718465.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli E110019],... gi\|75231501, gi\|... - gi\|75231501\|ref\|ZP_00717870.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli B7A], gi\|... gi\|194414855, gi... - gi\|75211576\|ref\|ZP_00711655.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli B171], gi... gi\|73856159, gi\|... - gi\|74312682\|ref\|YP_311101.1\| hypothetical protein SSON_2216 [Shigella sonnei Ss046], gi\|73856159\|gb\|...	254.0	[0..1]	[362..1]
gi\|124526736, gi... - gi\|124526736\|ref\|ZP_01698645.1\| PfkB domain protein [Escherichia coli B], gi\|124501792\|gb\|EAY49254.1... gi\|169754451, gi... - gi\|170019523\|ref\|YP_001724477.1\| hypothetical protein EcolC_1488 [Escherichia coli ATCC 8739], gi\|16... gi\|157161642, gi... - gi\|75196204\|ref\|ZP_00706274.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli HS], gi\|1... gi\|187427443, gi... - gi\|75177064\|ref\|ZP_00697171.1\| COG0524: Sugar kinases, ribokinase family [Shigella boydii BS512], gi... gi\|194436114, gi... - gi\|83588141\|ref\|ZP_00926766.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli 101-1], g... gi\|253978242, gi... - gi\|254288935\|ref\|YP_003054683.1\| predicted kinase [Escherichia coli BL21(DE3)], gi\|253978242\|gb\|ACT4... gi\|251785527, gi... - gi\|251785527\|ref\|YP_002999831.1\| hypothetical protein B21_02048 [Escherichia coli BL21], gi\|24237780... gi\|253974075, gi... - gi\|254162174\|ref\|YP_003045282.1\| predicted kinase [Escherichia coli B str. REL606], gi\|253974075\|gb\|...	253.0	[0..1]	[362..1]
gi\|227835566, gi... - gi\|227887216\|ref\|ZP_04005021.1\| PfkB family carbohydrate kinase [Escherichia coli 83972], gi\|2278355... gi\|26248543, gi\|... - gi\|26248543\|ref\|NP_754583.1\| hypothetical protein c2695 [Escherichia coli CFT073], gi\|26108948\|gb\|AA...	253.0	[0..1]	[362..1]
gi\|218690311, gi... - gi\|218690311\|ref\|YP_002398523.1\| hypothetical protein ECED1_2609 [Escherichia coli ED1a], gi\|2184278... gi\|110343962, gi... - gi\|110642370\|ref\|YP_670100.1\| hypothetical protein ECP_2200 [Escherichia coli 536], gi\|110343962\|gb\|... gi\|190909686, gi... - gi\|75242977\|ref\|ZP_00726683.1\| COG0524: Sugar kinases, ribokinase family [Escherichia coli F11], gi\|...	253.0	[0..1]	[362..1]

Back

Predicted Domain #1

Region A:
Residues: [1-362]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNREKEILA ILRRNPLIQQ NEIADMLQIS RSRVAAHIMD LMRKGRIKGK GYILTEQEYC  60
   61 VVVGTINMDI RGMADIRYPQ SASHPGTIHC SAGGVGRNIA HNLALLGRDV HLLSVIGDDF 120
  121 YGEMLLEETR RAGVNVSGCV RLHGQSTSTY LAIANRDDQT VLAINDTHLL EQLTPQLLNG 180
  181 SRDLLRHAGV VLADCNLTAE ALEWVFTLAD EIPVFVDTVS EFKAGKIKHW LAHIHTLKPT 240
  241 LPELEILWGQ AITSDADRNT AVNALHQQGV QQLFVYLPDE SVYCSEKDGE QFLLTAPAHT 300
  301 TVDSFGADDG FMAGLVYSFL EGYSFRDSAR FAVACAAISR ASGSLNNPTL SADNALSLVP 360
  361 MV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1vm7A
Description:	Crystal structure of Ribokinase (TM0960) from Thermotoga maritima at 2.15 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribokinase activity	4.13972810632318	bayes_pls_golite062009
carbohydrate kinase activity	3.53872211951287	bayes_pls_golite062009
kinase activity	2.28531824242987	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.27980720248925	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
phosphofructokinase activity	1.98381934960918	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.673555832721854	bayes_pls_golite062009
binding	0.2717506679077	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: