YRC Public Data Repository - Protein Structure Prediction

Protein:	UHPA_ECOLI
Organism:	Escherichia coli
Length:	196 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UHPA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|53688577 - gi\|53688577\|ref\|ZP_00110736.2\| COG2197: Response regulator containing a CheY-like receiver domain an...	174.0	[0..1]	[192..1]
gi\|196252895, gi... - gi\|196252895\|ref\|ZP_03151542.1\| two component transcriptional regulator, LuxR family [Clostridium th... gi\|67873312, gi\|... - gi\|67873312\|ref\|ZP_00503591.1\| regulatory protein, LuxR:Response regulator receiver [Clostridium the...	173.0	[0..2]	[194..4]
gi\|47555239, gi\|... - gi\|47568085\|ref\|ZP_00238790.1\| DNA-binding response regulator [Bacillus cereus G9241], gi\|47555239\|g... gi\|228675259, gi... - gi\|229108243\|ref\|ZP_04237865.1\| DNA-binding response regulator [Bacillus cereus Rock1-15], gi\|228675... gi\|229042495, gi... - gi\|229042495\|ref\|ZP_04190240.1\| DNA-binding response regulator [Bacillus cereus AH676], gi\|228726848... gi\|229194950, gi... - gi\|229194950\|ref\|ZP_04321731.1\| DNA-binding response regulator [Bacillus cereus m1293], gi\|228588518...	171.0	[0..1]	[194..1]
gi\|25298782 - pir\|\|AC2385 two-component response regulator all4635 [imported] - Nostoc sp. (strain PCC 7120) gi\|17232127, gi\|... - gi\|17232127\|ref\|NP_488675.1\| two-component response regulator [Nostoc sp. PCC 7120], gi\|17133772\|dbj...	170.0	[0..1]	[192..1]
gi\|71916622, gi\|... - gi\|72162890\|ref\|YP_290547.1\| LuxR response regulator receiver [Thermobifida fusca YX], gi\|71916622\|g...	170.0	[0..2]	[194..12]
gi\|196022296, gi... - gi\|196046921\|ref\|ZP_03114142.1\| DNA-binding response regulator, LuxR family [Bacillus cereus 03BB108... gi\|228927331, gi... - gi\|228927331\|ref\|ZP_04090391.1\| DNA-binding response regulator [Bacillus thuringiensis serovar pondi... gi\|218535372, gi... - gi\|218903406\|ref\|YP_002451240.1\| DNA-binding response regulator, LuxR family [Bacillus cereus AH820]... gi\|228914867, gi... - gi\|228914867\|ref\|ZP_04078473.1\| DNA-binding response regulator [Bacillus thuringiensis serovar pulsi... gi\|227003571, gi... - gi\|227814920\|ref\|YP_002814929.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str... gi\|225864244, gi... - gi\|225864244\|ref\|YP_002749622.1\| DNA-binding response regulator, LuxR family [Bacillus cereus 03BB10... gi\|167531545, gi... - gi\|167632733\|ref\|ZP_02391059.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|167639661, gi... - gi\|167639661\|ref\|ZP_02397931.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|170669108, gi... - gi\|170687057\|ref\|ZP_02878276.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|170128481, gi... - gi\|170706750\|ref\|ZP_02897209.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|177649611, gi... - gi\|177649611\|ref\|ZP_02932613.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|190563758, gi... - gi\|190565731\|ref\|ZP_03018651.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis Tsia... gi\|196033705, gi... - gi\|196033705\|ref\|ZP_03101116.1\| DNA-binding response regulator, LuxR family [Bacillus cereus W], gi\|... gi\|196029154, gi... - gi\|196039895\|ref\|ZP_03107198.1\| DNA-binding response regulator, LuxR family [Bacillus cereus NVH0597... gi\|49331108, gi\|... - gi\|49479552\|ref\|YP_036377.1\| response regulator [Bacillus thuringiensis serovar konkukian str. 97-27... gi\|52143191, gi\|... - gi\|52143191\|ref\|YP_083638.1\| response regulator [Bacillus cereus E33L], gi\|51976660\|gb\|AAU18210.1\| r... gi\|47527561, gi\|... - gi\|47527561\|ref\|YP_018910.1\| LuxR family DNA-binding response regulator [Bacillus anthracis str. 'Am... gi\|49185120, gi\|... - gi\|49185120\|ref\|YP_028372.1\| LuxR family DNA-binding response regulator [Bacillus anthracis str. Ste... gi\|65319569, gi\|... - gi\|65319569\|ref\|ZP_00392528.1\| COG2197: Response regulator containing a CheY-like receiver domain an... gi\|30256908, gi\|... - gi\|30262277\|ref\|NP_844654.1\| LuxR family DNA-binding response regulator [Bacillus anthracis str. Ame... gi\|254760128 - gi\|254760128\|ref\|ZP_05212152.1\| DNA-binding response regulator [Bacillus anthracis str. Australia 94... gi\|254751608 - gi\|254751608\|ref\|ZP_05203645.1\| DNA-binding response regulator [Bacillus anthracis str. Vollum] gi\|165870591, gi... - gi\|165870591\|ref\|ZP_02215245.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str.... gi\|254743522 - gi\|254743522\|ref\|ZP_05201207.1\| DNA-binding response regulator [Bacillus anthracis str. Kruger B] gi\|254737292 - gi\|254737292\|ref\|ZP_05194996.1\| DNA-binding response regulator [Bacillus anthracis str. Western Nort... gi\|254722254 - gi\|254722254\|ref\|ZP_05184042.1\| DNA-binding response regulator [Bacillus anthracis str. A1055] gi\|254684846 - gi\|254684846\|ref\|ZP_05148706.1\| DNA-binding response regulator [Bacillus anthracis str. CNEVA-9066] gi\|229265295, gi... - gi\|229600887\|ref\|YP_002866616.1\| DNA-binding response regulator, LuxR family [Bacillus anthracis str... gi\|229184493, gi... - gi\|229184493\|ref\|ZP_04311697.1\| DNA-binding response regulator [Bacillus cereus BGSC 6E1], gi\|228598... gi\|229121819, gi... - gi\|229121819\|ref\|ZP_04251039.1\| DNA-binding response regulator [Bacillus cereus 95/8201], gi\|2286616... gi\|228945885, gi... - gi\|228945885\|ref\|ZP_04108228.1\| DNA-binding response regulator [Bacillus thuringiensis serovar monte... gi\|228826031, gi... - gi\|228933571\|ref\|ZP_04096421.1\| DNA-binding response regulator [Bacillus thuringiensis serovar andal...	168.0	[0..2]	[194..3]
gi\|45506625, gi\|... - gi\|75908249\|ref\|YP_322545.1\| two component LuxR family transcriptional regulator [Anabaena variabili...	168.0	[0..1]	[192..1]
gi\|74491401, gi\|... - gi\|75761109\|ref\|ZP_00741104.1\| Two-component response regulator yhcZ [Bacillus thuringiensis serovar...	168.0	[0..2]	[194..9]
gi\|106885795, gi... - gi\|160882054\|ref\|YP_001561022.1\| two component LuxR family transcriptional regulator [Clostridium ph...	168.0	[0..2]	[194..4]
gi\|134051275, gi... - gi\|88945490\|ref\|ZP_01148660.1\| Response regulator receiver [Desulfotomaculum reducens MI-1], gi\|8892...	167.0	[0..1]	[195..1]

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Predicted Domain #1

Region A:
Residues: [1-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITVALIDDH LIVRSGFAQL LGLEPDLQVV AEFGSGREAL AGLPGRGVQV CICDISMPDI  60
   61 SGLELLSQLP KGMATIMLSV HDSPALVEQA LNAGARGFLS KRCSPDELIA AVHTVATGGC 120
  121 YLTPDIAIKL ASGRQDPLTK RERQVAEKLA QGMAVKEIAA ELGLSPKTVH VHRANLMEKL 180
  181 GVSNDVELAR RMFDGW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.0
Match:	1yioA
Description:	Crystallographic structure of response regulator StyR from Pseudomonas fluorescens
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	7.02872640261738	bayes_pls_golite062009
transcription regulator activity	5.23016166796951	bayes_pls_golite062009
signal transducer activity	4.51666042720644	bayes_pls_golite062009
molecular transducer activity	4.51666042720644	bayes_pls_golite062009
DNA binding	2.75354350283069	bayes_pls_golite062009
nucleic acid binding	2.67056525675208	bayes_pls_golite062009
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
transcription factor activity	2.12579037300919	bayes_pls_golite062009
binding	1.22427537074115	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: