YRC Public Data Repository - Protein Structure Prediction

Protein:	TYPH_ECOLI
Organism:	Escherichia coli
Length:	440 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYPH_ECOLI.

Description	E-value	Query Range	Subject Range
TYPH_PECAS - Thymidine phosphorylase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=deoA PE=... TYPH_ERWCT - Thymidine phosphorylase OS=Erwinia carotovora subsp. atroseptica GN=deoA PE=3 SV=1	456.0	[0..1]	[439..1]
gi\|77977213, gi\|... - gi\|77977213\|ref\|ZP_00832668.1\| COG0213: Thymidine phosphorylase [Yersinia intermedia ATCC 29909], gi...	454.0	[0..1]	[440..1]
TYPH_YERPS - Thymidine phosphorylase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=deoA PE=3 SV=1 TYPH_YERP3 - Thymidine phosphorylase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=deoA PE=3 ... TYPH_YERPY - Thymidine phosphorylase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=deoA PE=3 SV=1 TYPH_YERPS - Thymidine phosphorylase OS=Yersinia pseudotuberculosis GN=deoA PE=3 SV=1	452.0	[0..1]	[440..1]
gi\|186893933, gi... - gi\|186893933\|ref\|YP_001871045.1\| thymidine phosphorylase [Yersinia pseudotuberculosis PB1/+], gi\|186... gi\|117674939, gi... - gi\|77631568\|ref\|ZP_00794154.1\| COG0213: Thymidine phosphorylase [Yersinia pseudotuberculosis IP 3175...	451.0	[0..1]	[440..32]
gi\|238724993, gi... - gi\|77973609\|ref\|ZP_00829155.1\| COG0213: Thymidine phosphorylase [Yersinia frederiksenii ATCC 33641],...	449.0	[0..1]	[440..17]
gi\|162353031, gi... - gi\|77635642\|ref\|ZP_00797724.1\| COG0213: Thymidine phosphorylase [Yersinia pestis Angola], gi\|1624202...	449.0	[0..1]	[440..32]
gi\|161511295 - gi\|161511295\|ref\|NP_995015.2\| thymidine phosphorylase [Yersinia pestis biovar Microtus str. 91001] TYPH_YERPE - Thymidine phosphorylase OS=Yersinia pestis GN=deoA PE=3 SV=2	448.0	[0..1]	[440..1]
gi\|45438345, gi\|... - gi\|45443476\|ref\|NP_995015.1\| thymidine phosphorylase [Yersinia pestis biovar Microtus str. 91001], g...	446.0	[0..1]	[440..33]
gi\|238717880, gi... - gi\|77960326\|ref\|ZP_00824203.1\| COG0213: Thymidine phosphorylase [Yersinia mollaretii ATCC 43969], gi...	444.0	[0..1]	[440..12]
gi\|15024496, gi\|... - gi\|15894824\|ref\|NP_348173.1\| pyrimidine-nucleoside phosphorylase [Clostridium acetobutylicum ATCC 82... gi\|25286848 - pir\|\|F97090 pyrimidine-nucleoside phosphorylase [imported] - Clostridium acetobutylicum	442.0	[0..4]	[440..3]

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Predicted Domain #1

Region A:
Residues: [1-440]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD MTMPERVSLT  60
   61 MAMRDSGTVL DWKSLHLNGP IVDKHSTGGV GDVTSLMLGP MVAACGGYIP MISGRGLGHT 120
  121 GGTLDKLESI PGFDIFPDDN RFREIIKDVG VAIIGQTSSL APADKRFYAT RDITATVDSI 180
  181 PLITASILAK KLAEGLDALV MDVKVGSGAF MPTYELSEAL AEAIVGVANG AGVRTTALLT 240
  241 DMNQVLASSA GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGKLA KDDAEARAKL 300
  301 QAVLDNGKAA EVFGRMVAAQ KGPTDFVENY AKYLPTAMLT KAVYADTEGF VSEMDTRALG 360
  361 MAVVAMGGGR RQASDTIDYS VGFTDMARLG DQVDGQRPLA VIHAKDENNW QEAAKAVKAA 420
  421 IKLADKAPES TPTVYRRISE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	120.0
Match:	1azyA
Description:	Thymidine phosphorylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring pentosyl groups	2.4903133160045	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.43457627723298	bayes_pls_golite062009
catalytic activity	1.99182579317454	bayes_pls_golite062009
transferase activity	1.24273940197065	bayes_pls_golite062009
binding	0.410028762000886	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: