YRC Public Data Repository - Protein Structure Prediction

Protein:	TPIS_ECOLI
Organism:	Escherichia coli
Length:	255 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPIS_ECOLI.

Description	E-value	Query Range	Subject Range
TPIS_CARHZ - Triosephosphate isomerase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2...	339.0	[0..1]	[247..1]
TPIS_ROSS1 - Triosephosphate isomerase OS=Roseiflexus sp. (strain RS-1) GN=tpiA PE=3 SV=1	321.0	[0..1]	[246..1]
gi\|71983330 - gi\|71983330\|gb\|AAZ57433.1\| triose-phosphate isomerase [Orientobilharzia turkestanicum]	319.0	[0..2]	[248..5]
gi\|111075005 - gi\|111075005\|gb\|ABH04859.1\| triosephosphate isomerase [Heliobacillus mobilis]	317.0	[0..1]	[247..1]
gi\|223374 - gi\|223374\|prf\|\|0801190A isomerase,triosephosphate TPIS_RABIT - Triosephosphate isomerase OS=Oryctolagus cuniculus GN=TPI1 PE=1 SV=1	317.0	[0..2]	[250..4]
gi\|134053521, gi... - gi\|88946882\|ref\|ZP_01149946.1\| Triosephosphate isomerase [Desulfotomaculum reducens MI-1], gi\|889236...	317.0	[0..1]	[249..1]
TPISB_DANRE - Triosephosphate isomerase B OS=Danio rerio GN=tpi1b PE=2 SV=1	317.0	[0..2]	[250..4]
TPIS_LACAC - Triosephosphate isomerase OS=Lactobacillus acidophilus GN=tpiA PE=3 SV=1 gi\|227903583, gi... - gi\|227903583\|ref\|ZP_04021388.1\| triosephosphate isomerase [Lactobacillus acidophilus ATCC 4796], gi\|... TPIS_LACAC - Triosephosphate isomerase OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) GN=t...	317.0	[0..2]	[248..3]
gi\|55730014 - gi\|55730014\|emb\|CAH91732.1\| hypothetical protein [Pongo abelii] TPIS_PONAB - Triosephosphate isomerase OS=Pongo abelii GN=TPI1 PE=2 SV=1	317.0	[0..2]	[250..5]
gi\|66360365, gi\|... - gi\|66360366\|pdb\|1WYI\|B Chain B, Human Triosephosphate Isomerase Of New Crystal Form, gi\|66360365\|pdb...	317.0	[0..2]	[250..6]

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Predicted Domain #1

Region A:
Residues: [1-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHPLVMGNW KLNGSRHMVH ELVSNLRKEL AGVAGCAVAI APPEMYIDMA KREAEGSHIM  60
   61 LGAQNVDLNL SGAFTGETSA AMLKDIGAQY IIIGHSERRT YHKESDELIA KKFAVLKEQG 120
  121 LTPVLCIGET EAENEAGKTE EVCARQIDAV LKTQGAAAFE GAVIAYEPVW AIGTGKSATP 180
  181 AQAQAVHKFI RDHIAKVDAN IAEQVIIQYG GSVNASNAAE LFAQPDIDGA LVGGASLKAD 240
  241 AFAVIVKAAE AAKQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.69897
Match:	1tmhA
Description:	Triosephosphate isomerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
triose-phosphate isomerase activity	5.94525596131351	bayes_pls_golite062009
intramolecular oxidoreductase activity	4.11751506069887	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	3.62219160185043	bayes_pls_golite062009
isomerase activity	2.06271139232842	bayes_pls_golite062009
binding	1.80264931081179	bayes_pls_golite062009
catalytic activity	1.7524198174984	bayes_pls_golite062009
protein binding	0.33788557654084	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: