YRC Public Data Repository - Protein Structure Prediction

Protein:	TIG_ECOLI
Organism:	Escherichia coli
Length:	432 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|66472064 - gi\|66472064\|dbj\|BAD98926.1\| trigger factor tag [Expression vector pColdTF]	360.0	[0..1]	[432..12]
gi\|149291409, gi... - gi\|149364996\|ref\|ZP_01887031.1\| Trigger factor [Yersinia pestis CA88-4125], gi\|149291409\|gb\|EDM41483... TIG_YERPP - Trigger factor OS=Yersinia pestis (strain Pestoides F) GN=tig PE=3 SV=1 gi\|22124933, gi\|... - gi\|22124933\|ref\|NP_668356.1\| trigger factor [Yersinia pestis KIM], gi\|21957772\|gb\|AAM84607.1\|AE01370... TIG_YERPB - Trigger factor OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=tig PE=3 SV=1 TIG_YERPY - Trigger factor OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=tig PE=3 SV=1 TIG_YERPS - Trigger factor OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=tig PE=3 SV=1 gi\|45440622, gi\|... - gi\|45440622\|ref\|NP_992161.1\| trigger factor [Yersinia pestis biovar Microtus str. 91001], gi\|4543547... gi\|165916055, gi... - gi\|89103166\|ref\|ZP_01175756.1\| COG0544: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger facto... gi\|15981096, gi\|... - gi\|218930188\|ref\|YP_002348063.1\| trigger factor [Yersinia pestis CO92], gi\|16123320\|ref\|NP_406633.1\|... gi\|229695128, gi... - gi\|229838762\|ref\|ZP_04458921.1\| peptidyl-prolyl cis/trans isomerase (trigger factor) [Yersinia pesti... gi\|229701007, gi... - gi\|229896084\|ref\|ZP_04511254.1\| peptidyl-prolyl cis/trans isomerase (trigger factor) [Yersinia pesti... gi\|229899330, gi... - gi\|229899330\|ref\|ZP_04514473.1\| peptidyl-prolyl cis/trans isomerase (trigger factor) [Yersinia pesti... TIG_YERPA - Trigger factor OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=tig PE=3 SV=1 TIG_YERPN - Trigger factor OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=tig PE=3 SV=1 TIG_YERPG - Trigger factor OS=Yersinia pestis bv. Antiqua (strain Angola) GN=tig PE=3 SV=1 TIG_YERP3 - Trigger factor OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=tig PE=3 SV=1 TIG_YERPS - Trigger factor OS=Yersinia pseudotuberculosis GN=tig PE=3 SV=1 gi\|165921498, gi... - gi\|165926570\|ref\|ZP_02222402.1\| trigger factor [Yersinia pestis biovar Orientalis str. F1991016], gi... gi\|166213027, gi... - gi\|166213027\|ref\|ZP_02239062.1\| trigger factor [Yersinia pestis biovar Antiqua str. B42003004], gi\|1... gi\|166011084, gi... - gi\|166011084\|ref\|ZP_02231982.1\| trigger factor [Yersinia pestis biovar Antiqua str. E1979001], gi\|16... gi\|167421613, gi... - gi\|167421613\|ref\|ZP_02313366.1\| trigger factor [Yersinia pestis biovar Orientalis str. MG05-1020], g... gi\|167399486, gi... - gi\|167399486\|ref\|ZP_02305010.1\| trigger factor [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|1... gi\|167471040 - gi\|167471040\|ref\|ZP_02335744.1\| trigger factor [Yersinia pestis FV-1] gi\|167423079, gi... - gi\|167423079\|ref\|ZP_02314832.1\| trigger factor [Yersinia pestis biovar Mediaevalis str. K1973002], g... TIG_YERPE - Trigger factor OS=Yersinia pestis GN=tig PE=3 SV=1	358.0	[0..1]	[430..1]
TIG_SODGM - Trigger factor OS=Sodalis glossinidius (strain morsitans) GN=tig PE=3 SV=1	357.0	[0..1]	[432..1]
gi\|238788007, gi... - gi\|77974304\|ref\|ZP_00829845.1\| COG0544: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger facto...	356.0	[0..1]	[430..1]
TIG_PECAS - Trigger factor OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=tig PE=3 SV=1 TIG_ERWCT - Trigger factor OS=Erwinia carotovora subsp. atroseptica GN=tig PE=3 SV=1	355.0	[0..1]	[430..1]
gi\|238729046, gi... - gi\|77979392\|ref\|ZP_00834811.1\| COG0544: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger facto...	355.0	[0..1]	[430..1]
gi\|90410781, gi\|... - gi\|90410781\|ref\|ZP_01218796.1\| trigger factor [Photobacterium profundum 3TCK], gi\|90328412\|gb\|EAS447...	354.0	[0..1]	[432..1]
gi\|238715488, gi... - gi\|77956938\|ref\|ZP_00821010.1\| COG0544: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger facto...	352.0	[0..1]	[430..1]
gi\|77962965, gi\|... - gi\|77962965\|ref\|ZP_00826780.1\| COG0544: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger facto...	351.0	[0..1]	[430..1]
TIG_SALPC - Trigger factor OS=Salmonella paratyphi C (strain RKS4594) GN=tig PE=3 SV=1 TIG_SALCH - Trigger factor OS=Salmonella choleraesuis GN=tig PE=3 SV=1 TIG_SALCH - Trigger factor OS=Salmonella choleraesuis GN=tig PE=3 SV=1 TIG_SALCH - Trigger factor OS=Salmonella choleraesuis (strain SC-B67) GN=tig PE=3 SV=1	351.0	[0..1]	[432..1]

Back

Predicted Domain #1

Region A:
Residues: [1-432]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVSVETTQG LGRRVTITIA ADSIETAVKS ELVNVAKKVR IDGFRKGKVP MNIVAQRYGA  60
   61 SVRQDVLGDL MSRNFIDAII KEKINPAGAP TYVPGEYKLG EDFTYSVEFE VYPEVELQGL 120
  121 EAIEVEKPIV EVTDADVDGM LDTLRKQQAT WKEKDGAVEA EDRVTIDFTG SVDGEEFEGG 180
  181 KASDFVLAMG QGRMIPGFED GIKGHKAGEE FTIDVTFPEE YHAENLKGKA AKFAINLKKV 240
  241 EERELPELTA EFIKRFGVED GSVEGLRAEV RKNMERELKS AIRNRVKSQA IEGLVKANDI 300
  301 DVPAALIDSE IDVLRRQAAQ RFGGNEKQAL ELPRELFEEQ AKRRVVVGLL LGEVIRTNEL 360
  361 KADEERVKGL IEEMASAYED PKEVIEFYSK NKELMDNMRN VALEEQAVEA VLAKAKVTEK 420
  421 ETTFNELMNQ QA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.522879
Match:	1w26A
Description:	Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidyl-prolyl cis-trans isomerase activity	4.0615867467963	bayes_pls_golite062009
cis-trans isomerase activity	3.99265212272703	bayes_pls_golite062009
isomerase activity	2.31710030777753	bayes_pls_golite062009
macrolide binding	1.71427500929512	bayes_pls_golite062009
FK506 binding	1.49236065710546	bayes_pls_golite062009
catalytic activity	0.885282592863018	bayes_pls_golite062009
protein binding	0.435609235063535	bayes_pls_golite062009
binding	0.3989771181671	bayes_pls_golite062009
drug binding	0.386165046836496	bayes_pls_golite062009
unfolded protein binding	0.27473817613726	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: